K. Ganeshaguru

University of Sydney — Australia

Medicine · Health Sciences

38h-index3.8kcitations107works0.02yr avg
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Research Topics

Chronic Lymphocytic Leukemia Research(37), Acute Lymphoblastic Leukemia research(35), Biochemical and Molecular Research(21), Acute Myeloid Leukemia Research(14), Drug Transport and Resistance Mechanisms(9)

Publications107 total

Deoxyribonucleoside Triphosphate Pools in Human Bone Marrow and Leukaemic Cells
Antibiotics and chemotherapy/Antibiotica et chemotherapia·2015· 8 cited
Dose-ranging study of AVI-4658 to induce dystrophin expression in selected duchenne muscular dystrophy (DMD) patients
2012· 1 cited
P05 Induction of dystrophin in Duchenne muscular dystrophy patients by antisense oligonucleotide AVI-4658 restores the dystrophin-associated glycoprotein complex
Neuromuscular Disorders·2010
P07 Translation related clinical trials in duchenne muscular dystrophy (DMD) in the UK
Neuromuscular Disorders·2010
Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity
European Journal of Pharmacology·2009· 14 cited
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro
Leukemia·2006· 76 cited
Generation of reactive oxygen species by parthenolide rapidly and selectively induces apoptosis of B-chronic lymphocytic leukaemia (CLL) cells via a p53 independent pathway
UCL Discovery (University College London)·2006
An In Vitro Model of Proliferating CLL Cells for Drug Sensitivity Analysis.
Blood·2005
CCK2 gastrin receptor as a potential target for therapy in leukaemia cell lines
Oncology Reports·2005· 6 cited
Selective Apoptotic Killing of Malignant Hemopoietic Cells by Antibody-Targeted Delivery of an Amphipathic Peptide
Cancer Research·2005· 69 cited
Glucosylceramide Synthetase Inhibitors Sensitise B-CLL Cells to Cytotoxic Agents without Reversing P-gp Functional Activity.
Blood·2004· 1 cited
The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.
Blood·2004
The Role of Multidrug Resistance Proteins and Drug Sensitivity in Relation to Poor Prognosis Identified by ZAP-70 Expression and IgVH Mutation Status in B-CLL.
Blood·2004
Zap-70 and IgVH Mutation Status in Combination with p53 Functional Analysis Identifies the Response of Poor Prognosis B-CLL Patients to Conventional Cytotoxic Agents.
Blood·2004· 1 cited
Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine.
PubMed·2004· 93 cited
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs
Blood·2003· 44 citedOpen Access
Cytotoxic drugs enhance the <i>ex vivo</i> sensitivity of malignant cells from a subset of acute myeloid leukaemia patients to apoptosis induction by tumour necrosis factor receptor‐related apoptosis‐inducing ligand
British Journal of Haematology·2003· 28 cited
Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis
Blood·2003· 82 cited
Expression of breast cancer resistance protein in malignant cells from patients with leukaemia.
UCL Discovery (University College London)·2003
Multidrug resistance and myelomonocytic leukaemia in gaucher's disease.
PubMed·2003· 5 cited
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Frequent Co-authors

A. V. Hoffbrand(20), Atul Mehta(15), Dylan T. Jones(10), A. Victor Hoffbrand(10), A. Victor Hoffbrand(9), George Janossy(8), H. G. Prentice(8), H. G. Prentice(8), R. Gitendra Wickremasinghe(6), Martin H.N. Tattersall(5), Panayiotis Panayiotidis(4), Letizia Foroni(4), Daniel Catovsky(4), Mark W. Lowdell(4), R G Wickremasinghe(4), A. Piga(4), E. Tripp(4), B. Wonke(3), P. Llewellin(3), Janet North(3)