Toshiki Ohkubo

Keio University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index254citations22works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(8), HIV/AIDS drug development and treatment(6), Biochemical and Molecular Research(6), Lung Cancer Research Studies(5), Drug Transport and Resistance Mechanisms(4)

Publications22 total

Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury
Stem Cells·2018· 127 citedOpen Access
A phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine.
Journal of Clinical Oncology·2013· 4 cited
Plasma, Intestine and Tumor Levels of 5-Fluorouracil in Mice Bearing L1210 Ascites Tumor Following Oral Administration of 5-Fluorouracil, UFT (Mixed Compound of Tegafur and Uracil), Carmofur and 5'-Deoxy-5-fluorouridine.
Biological and Pharmaceutical Bulletin·2001· 10 citedOpen Access
Effect of Etoposide on the Influx and Intracellular Accumulation of Cytosine Arabinoside in Human and Murine Leukemic Cell Lines and in Human Peripheral Leukemic Cells.
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics·1996· 1 citedOpen Access
Effect of Etoposide on Cell Cycle Progression in Ll210 Murine Ascites Tumor.
Japanese Journal of Hospital Pharmacy·1996· 1 citedOpen Access
Heterogeneous Effects of G-CSF and GM-CSF on Cell Growth and Ara-C Cytotoxicity in Childhood Leukemias Which Express Myeloid Markers
Leukemia & lymphoma/Leukemia and lymphoma·1996· 4 cited
Increased Deoxycytidine Kinase Activity by Etoposide in L1210 Murine Leukemic Cells.
Biological and Pharmaceutical Bulletin·1996· 15 citedOpen Access
Effects of UFT (Mixed Compound of Tegafur and Uracil) on Cell Kinetics and Inhibition of Thymidylate Synthase in L1210 Ascites Tumor
Cancer Investigation·1995· 4 cited
Enhanced Incorporation of 1-β-D-Arabinofuranosylcytosine by Pretreatment with Etoposide
Cancer Investigation·1993· 10 cited
Effects of 5-Fluorouracil and a Combination of Tegafur and Uracil (UFT) on Nucleotide Metabolism in L1210 Ascites Tumor
Cancer Investigation·1993· 5 cited
Membrane transport of 1-β-d-arabinofuranosylcytosine and accumulation of 1-β-d-arabinofuranosylcytosine 5′-triphosphate in P388 murine leukemic cells resistant to vincristine
Leukemia Research·1991· 4 cited
Decreased DNA polymerase sensitivity to 1-β-d-arabinofuranosylcytosine 5′-Triphosphate in P388 murine leukemic cells resistant to vincristine
Leukemia Research·1991· 11 cited
Intracellular dCTP/ARA-CTP Ratio and the Cytotoxic Effect of ARA-C
Cancer Investigation·1991· 8 cited
Deoxyribonucleoside triphosphate pools and ara-ctp levels in P388 murine leukemic cells treated with 1-B-D-Arabinofuranosylcytosine-5′ -stearylphosphate which is a newly synthesized derivative OF 1-B-D-arabinofuranosylcytosine
Medical Oncology and Tumor Pharmacotherapy·1990· 9 cited
Increased sensitivity to 1-β-d-arabinofuranosylcytosine in P388 murine leukemic cells resistant to etoposide
Leukemia Research·1989· 17 cited
Studies on the Relationship between Therapeutic Schedule and Antitumor Effect of Etoposide and Cytosine Arabinoside in Murine L1210 Leukemia
YAKUGAKU ZASSHI·1989· 5 citedOpen Access
Sequence-dependent antitumor effect of VP-16 and 1-β-d-arabinofuranosylcytosine in L1210 ascites tumor
European Journal of Cancer and Clinical Oncology·1988· 12 cited
Incorporation ofN 4-behenoyl-1-β-d-arabinofuranosylcytosine into DNA as 1-β-d-arabinofuranosylcytosine
Medical Oncology and Tumor Pharmacotherapy·1988· 6 cited
56 INCORPORATION OF N4-BEHENOLY-1-β-D-ARABINOFURANOSYLCYTOSINE (BHAC) INTO DNA AS l-β-D-ARABINOFURANOSYLCYTOSINE (ARA-C)
Pediatric Research·1988Open Access
102 SYNERGISTIC INTERACTION BETWEEN ETOPOSIDE AND 1-β-D-ARABINOFURANOSYLCYTOSINE
Pediatric Research·1988Open Access
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Frequent Co-authors

Minoru Sakurai(19), Hajime Kawasaki(18), Masamune Higashigawa(16), Kazuya Ooi(9), Hitoshi Kamiya(7), Masaru Ido(5), Yoshiyuki Kagawa(5), Hiroshi Kuwabara(5), Hiroki Hori(4), Kiyosu Taniguchi(3), Katsumi Sumida(3), Shoji Inagaki(3), Hideshi Kakito(3), Tsutomu Nobori(3), Minoru Hamazaki(2), Michio Kojima(2), Hidee Ochiai(2), Osahiko Tsuji(1), Keiko Sugai(1), Ryo Yamaguchi(1)