Mark Meloche

University of British Columbia — Canada

Medicine · Health Sciences

14h-index901citations46works0.02yr avg
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Research Topics

Pancreatic function and diabetes(30), Diabetes and associated disorders(14), Diabetes Management and Research(11), Diabetes Treatment and Management(8), RNA Interference and Gene Delivery(4)

Publications45 total

Dual role of interleukin‐1β in islet amyloid formation and its β‐cell toxicity: <scp>I</scp> mplications for type 2 diabetes and islet transplantation
Diabetes Obesity and Metabolism·2017· 38 cited
Fluorescent cholangiography in laparoscopic cholecystectomy: the initial Canadian experience
The American Journal of Surgery·2016· 34 cited
Percutaneous Autologous Pancreatic Islet Cell Transplantation for Traumatic Pancreatic Injury
The Journal of Clinical Endocrinology & Metabolism·2015· 13 citedOpen Access
Amyloid-Induced Fas Upregulation is Mediated by IL-1β Signalling in Human Islets
Canadian Journal of Diabetes·2014
Amyloid Formation Reduces Phospho-PKB Levels in Islet β-Cells Which is Restored by Blocking IL-1β Signalling
Canadian Journal of Diabetes·2014
Blocking IL-1 Receptor Signalling Restores Impaired Processing of Pro-Islet Amyloid Polypeptide and Reduces Amyloid Formation in Human Islets
Canadian Journal of Diabetes·2014
Endocrine Therapeutic Delivery
2014
B7-H4 Expression in Normal and Diseased Human Islet β Cells
Pancreas·2013· 18 cited
The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation
Diabetologia·2012· 45 citedOpen Access
The IL-1 Receptor Antagonist Anakinra Enhances Survival and Function of Human Islets during Culture: Implications in Clinical Islet Transplantation
Transplantation·2012
The IL-1 Receptor Antagonist Anakinra Enhances Survival and Function of Human Islets during Culture: Implications in Clinical Islet Transplantation
Canadian Journal of Diabetes·2012· 2 cited
IL-1 Receptor Blockade as a Means of Reducing β-Cell Death in Human Islets during Pre-transplant Culture
Canadian Journal of Diabetes·2012
Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
International Journal of Endocrinology·2012· 4 citedOpen Access
Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy
Transplantation·2011· 213 cited
Improving Islet Engraftment by Gene Therapy
Journal of Transplantation·2011· 18 citedOpen Access
B7-H4 Pathway in Islet Transplantation and<i>β</i>-Cell Replacement Therapies
Journal of Transplantation·2011· 9 citedOpen Access
TREATMENT WITH EXENATIDE PRESERVES BETA CELL MASS IN HUMAN ISLETS DURING CULTURE: IMPLICATIONS FOR ISLET TRANSPLANTATION
Transplantation·2010
A COMPARISON OF ISLET TRANSPLANTATION WITH MEDICAL THERAPY ON THE PROGRESSION OF DIABETIC COMPLICATIONS
Transplantation·2010
FACTORS AFFECTING EARLY GRAFT FUNCTION IN ISLET TRANSPLANTATION
Transplantation·2010
THE GLUCAGON-LIKE PEPTIDE-1 ANALOGUE EXENATIDE REDUCES AMYLOID-INDUCED BETA-CELL TOXICITY IN CULTURED HUMAN ISLETS
Transplantation·2010
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Frequent Co-authors

Garth L. Warnock(28), Ziliang Ao(14), Lucy Marzban(13), Z. Ao(10), David Thompson(9), Paul Keown(7), Timothy J. Kieffer(7), Stephen Ho(6), A.M.J. Buchan(6), Nooshin Safikhan(6), Yoo Jin Park(6), Michelle Fung(5), EDWARD CHOICE(5), Thomas D. Madden(5), C. Bruce Verchere(5), Breay W. Paty(4), R. Jean Shapiro(4), Graydon S. Meneilly(4), Sharon Kozak(4), J. Kondi(3)