Jacquelynn J. Cook

United States Military Academy — United States

Medicine · Health Sciences

37h-index3.9kcitations110works0.02yr avg
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Research Topics

Platelet Disorders and Treatments(33), Antiplatelet Therapy and Cardiovascular Diseases(15), Heparin-Induced Thrombocytopenia and Thrombosis(15), Cell Adhesion Molecules Research(12), Alzheimer's disease research and treatments(11)

Publications110 total

Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193
Molecular Imaging and Biology·2015· 13 cited
Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys
Bioorganic & Medicinal Chemistry Letters·2015· 16 citedOpen Access
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
Bioorganic & Medicinal Chemistry Letters·2015· 22 cited
The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey
Psychopharmacology·2013· 31 cited
In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232
Journal of Pharmacology and Experimental Therapeutics·2013· 126 cited
[ <sup>11</sup> C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor
ACS Medicinal Chemistry Letters·2013· 25 citedOpen Access
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase
ACS Medicinal Chemistry Letters·2013· 36 citedOpen Access
Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human
NeuroImage·2012· 27 cited
Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease
Journal of Neuroscience Research·2012· 65 cited
Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function
NeuroImage·2011· 11 cited
Discovery of MK-3168: A clinical PET tracer as a target engagement biomarker for FAAH
Abstracts of papers - American Chemical Society·2011
[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey
Nuclear Medicine and Biology·2011· 28 cited
Comparison of the <i>In Vivo</i> Distribution of Four Different Annexin A5 Adducts in Rhesus Monkeys
International Journal of Molecular Imaging·2011· 2 citedOpen Access
Head-to-head comparison of treatment effects of odanacatib to alendronate in the ovariectomized rhesus monkey: A longitudinal multi-modality imaging study
Bone·2011· 2 cited
A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody
Journal of Pharmacology and Experimental Therapeutics·2011· 87 cited
Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-<i>b</i>]pyridines as β-Amyloid PET Ligands and Identification of MK-3328
ACS Medicinal Chemistry Letters·2011· 23 citedOpen Access
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 6 citedOpen Access
P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position
Bioorganic & Medicinal Chemistry Letters·2010· 4 citedOpen Access
Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor
NeuroImage·2010· 34 cited
The synthesis and preclinical evaluation in rhesus monkey of [<sup>18</sup>F]MK‐6577 and [<sup>11</sup>C]CMPyPB glycine transporter 1 positron emission tomography radiotracers
Synapse·2010· 33 cited
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Frequent Co-authors

Marie A. Holahan(19), Maria T. Stranieri(14), Joseph J. Lynch(14), Gary R. Sitko(10), Joseph P. Vacca(9), Robert J. Gould(8), George D. Hartman(8), Stefan Niewiarowski(7), Sidney D. Lewis(7), Bobby J. Lucas(7), Elizabeth A. Lyle(7), Sandra Sanabria Bohórquez(6), Stacey O’Malley(6), Harold G. Selnick(6), Julie A. Krueger(6), Jules A. Shafer(6), Bohumil Bednář(6), Robert J. Lynch(6), Zhizhen Zeng(5), Mangay Williams(5)