Xian‐Yun Jiao

Aptose Biosciences (United States) — United States

Chemistry · Physical Sciences

19h-index1.2kcitations30works0.02yr avg
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Research Topics

Organophosphorus compounds synthesis(8), Radical Photochemical Reactions(6), Receptor Mechanisms and Signaling(6), Pancreatic function and diabetes(5), Diabetes Treatment and Management(4)

Publications30 total

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity
ACS Chemical Biology·2019· 91 cited
Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates
ACS Medicinal Chemistry Letters·2018· 14 citedOpen Access
5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
ACS Medicinal Chemistry Letters·2016· 22 citedOpen Access
C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
ACS Medicinal Chemistry Letters·2014· 15 citedOpen Access
Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
ACS Medicinal Chemistry Letters·2014· 24 citedOpen Access
Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles
ACS Medicinal Chemistry Letters·2013· 81 citedOpen Access
Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies
ACS Medicinal Chemistry Letters·2013· 26 citedOpen Access
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist
ACS Medicinal Chemistry Letters·2012· 89 citedOpen Access
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 63 citedOpen Access
Discovery and optimization of a series of liver X receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 19 citedOpen Access
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Journal of Medicinal Chemistry·2012· 166 citedOpen Access
The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2009· 100 citedOpen Access
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 36 citedOpen Access
Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2
Molecular Pharmacology·2008· 154 cited
An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1
Analytical Biochemistry·2007· 9 cited
A Facile Route to Vinyl- and Arylphosphonates by Vinyl and Aryl Radical Trapping with (MeO)3P.
ChemInform·2003· 1 citedOpen Access
A Facile Route to Vinyl- and Arylphosphonates by Vinyl and Aryl Radical Trapping with (MeO)<sub>3</sub>P
The Journal of Organic Chemistry·2003· 53 cited
ChemInform Abstract: Vinylphosphonate Formation via a Novel Cyclization—Vinyl Radical Trapping Sequence.
ChemInform·1999
Vinylphosphonate Formation via a Novel Cyclization−Vinyl Radical Trapping Sequence
Journal of the American Chemical Society·1999· 45 cited
Asymmetric synthesis of a taxol C-ring by aldol condensation and radical cyclization
Tetrahedron·1997· 17 cited
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Frequent Co-authors

Frank Kayser(7), Julio C. Medina(7), Jonathan B. Houze(7), Paul J. Dransfield(6), Gayathri Swaminath(5), Jiwen Liu(5), Vatee Pattaropong(5), Run Zhuang(5), Daniel C.-H. Lin(5), David J. Kopecky(4), Mario Cardozo(4), Yingcai Wang(4), Sean P. Brown(4), Marc Vimolratana(4), Liusheng Zhu(4), Jian Luo(4), Jane Zhang(4), Xiaohui Du(4), Wesley G. Bentrude(4), David Crich(4)