Günther Kern

Medicine · Health Sciences

22h-index2.7kcitations98works8.02yr avg
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Research Topics

Cervical Cancer and HPV Research(7), Cancer therapeutics and mechanisms(6), Antibiotics Pharmacokinetics and Efficacy(5), Cancer Diagnosis and Treatment(5), Alcoholism and Thiamine Deficiency(5)

Publications98 total

Small molecules restore mutant mitochondrial DNA polymerase activity
Nature·2025· 8 citedOpen Access
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination
SLAS DISCOVERY·2021· 19 citedOpen Access
Development of an AchillesTAG degradation system and its application to control CAR-T activity
Current Research in Chemical Biology·2021· 20 citedOpen Access
Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase
Journal of Medicinal Chemistry·2020· 17 cited
Dynamics of human protein kinase Aurora A linked to drug selectivity
eLife·2018· 47 citedOpen Access
Author response: Dynamics of human protein kinase Aurora A linked to drug selectivity
2018Open Access
Dynamics of human protein kinases linked to drug selectivity
2018Open Access
Correction: Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
Scientific Reports·2015· 2 citedOpen Access
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
Scientific Reports·2015· 100 citedOpen Access
Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)
Journal of Medicinal Chemistry·2015· 68 cited
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914
Journal of Biological Chemistry·2015· 51 citedOpen Access
Toxicokinetic Insights are Critical to Understanding Renal Toxicity of Novel Polymyxin Analog
The FASEB Journal·2015· 1 cited
CCDC 1025296: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1013311: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization
Journal of Medicinal Chemistry·2014· 55 citedOpen Access
Preinvasive Carcinoma of the Cervix: Theory and Practice
Medical Entomology and Zoology·2014· 2 citedOpen Access
Fragment-Based Lead Discovery and Design
Journal of Chemical Information and Modeling·2014· 131 cited
Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers
Toxicological Sciences·2013· 87 citedOpen Access
A High-Throughput–Compatible Fluorescence Anisotropy-Based Assay for Competitive Inhibitors of Escherichia coli UDP-N-Acetylglucosamine Acyltransferase (LpxA)
SLAS DISCOVERY·2012· 11 citedOpen Access
Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor
Proceedings of the National Academy of Sciences·2012· 508 citedOpen Access
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Frequent Co-authors

Dorothee Kern(8), Gregory S. Basarab(6), P. Doig(6), Stewart L. Fisher(5), Gerhard Hübner(5), Vincent Galullo(5), Madhusudhan Gowravaram(5), Amy Kutschke(5), Grant K. Walkup(4), John P. Mueller(4), Karthick Vishwanathan(4), Amy Kimzey(4), Marshall Morningstar(4), Virna Schuck(4), Franz X. Schmid(4), E Kern-Bontke(4), Charles J. Eyermann(3), Holger Neef(3), Kai Tittmann(3), Margrit Killenberg‐Jabs(3)