Allison C. Chin

University of Leeds — United Kingdom

Medicine · Health Sciences

13h-index1.4kcitations28works0.02yr avg
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Research Topics

Telomeres, Telomerase, and Senescence(16), RNA Interference and Gene Delivery(13), Advanced biosensing and bioanalysis techniques(11), DNA and Nucleic Acid Chemistry(6), Cell death mechanisms and regulation(2)

Publications28 total

Role of patient and public involvement in implementation research: a consensus study
BMJ Quality & Safety·2018· 185 citedOpen Access
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
Neurosignals·2014· 82 citedOpen Access
Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types
Planta Medica·2011· 45 cited
In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator
Drug Metabolism and Pharmacokinetics·2010· 33 citedOpen Access
Chin, Allison - PacResDay 2010 ABSTRACT
2010Open Access
Renew, Refuel, and Rebuild
NEW SOLUTIONS A Journal of Environmental and Occupational Health Policy·2009
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
The Journal of Immunology·2008· 165 citedOpen Access
GRN163L, a Potent and Specific Inhibitor of Telomerase: Integrated Pharmacokinetic, Pharmacodynamic, and Safety Data Guides Design of Practical Treatment Regimens for Targeting Inhibitory Levels in Patients.
Blood·2006· 3 cited
GRN163L, a Novel and Potent Telomerase Inhibitor, Inhibits Myeloma Cell Growth In Vitro and In Vivo.
Blood·2005
GRN163L Inhibits Telomerase Activity in B-CLL Cells.
Blood·2005· 2 cited
The Telomerase Template Antagonist GRN163L in Combination with Chemotherapeutics Reduces Tumor Volume in Multiple Myeloma Xenograft Models.
Blood·2005
Telomerase Antagonists GRN163 and GRN163L Inhibit Tumor Growth and Increase Chemosensitivity of Human Hepatoma *
Hepatology·2005· 150 cited
Lipid modification of GRN163, an N3′ → P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
Oncogene·2005· 263 cited
Preclinical development of GRN163L, a telomerase inhibitor for cancer therapy
Cancer Research·2005
Telomerase inhibition: Structure-activity relationships among perylene-related drugs
Cancer Research·2005
The telomerase template antagonist GRN163L reduces tumor volume in a multiple myeloma xenograft model
Cancer Research·2005
Telomerase Inhibition, Telomere Shortening and Apoptotic Cell Death in Multiple Myeloma Cells Following Exposure to a Novel and Potent Telomerase Inhibitor (GRN163L), Targeting RNA component of Telomerase.
Blood·2004· 3 cited
Development of a competitive hybridization/ELISA assay for the determination of GRN163 and GRN163L in plasma.
Cancer Research·2004
Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase
ChemInform·2004
243 GRN163 and GRN163L, telomerase template antagonists, inhibit the growth of human hepatoma in vivo
Journal of Hepatology·2004
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Frequent Co-authors

Calvin B. Harley(11), Sergei Gryaznov(11), Krisztina Pongracz(7), Ellen Wunder(6), Ronald Pruzan(4), Mieczyslaw A. Piatyszek(4), Jerry W. Shay(3), Ning Go(3), Fanny C.F. Ip(3), Yung Hou Wong(3), Nancy Y. Ip(3), Kaida Wu(3), Malcolm A.S. Moore(3), Robert Tressler(3), Brittney‐Shea Herbert(2), Daria Zielińska(2), Akira Asai(2), Yuko Oshima(2), Shiro Akinaga(2), Yoshinori Yamashita(2)