Christine Guthrie

University of California, San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

64h-index15.9kcitations151works0.02yr avg
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Research Topics

RNA Research and Splicing(119), RNA and protein synthesis mechanisms(111), RNA modifications and cancer(95), Genomics and Chromatin Dynamics(13), Fungal and yeast genetics research(12)

Publications151 total

Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant
iScience·2019· 8 citedOpen Access
Prp8 impacts cryptic but not alternative splicing frequency
Proceedings of the National Academy of Sciences·2019· 15 citedOpen Access
Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope
Molecular Biology of the Cell·2018· 3 cited
Identification of the Novel<i>Nup188-brr7</i>Allele in a Screen for Cold-Sensitive mRNA Export Mutants in<i>Saccharomyces cerevisiae</i>
G3 Genes Genomes Genetics·2018· 6 citedOpen Access
Brr2 is a splicing fidelity factor
2018Open Access
Prp8 positioning of U5 snRNA is linked to 5′ splice site recognition
RNA·2018· 17 citedOpen Access
Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency
Proceedings of the National Academy of Sciences·2017· 27 citedOpen Access
The histone variant H2A.Z promotes splicing of weak introns
Genes & Development·2017· 27 citedOpen Access
Genetics and biochemistry remain essential in the structural era of the spliceosome
Methods·2017· 18 citedOpen Access
Evolutionarily Conserved Polyadenosine RNA Binding Protein Nab2 Cooperates with Splicing Machinery To Regulate the Fate of Pre-mRNA
Molecular and Cellular Biology·2016· 80 citedOpen Access
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity
Journal of Biological Chemistry·2016· 16 citedOpen Access
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing
RNA·2016· 32 citedOpen Access
A new communication hub in the RNA world
Nature Structural & Molecular Biology·2016· 1 cited
Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough
PLoS Genetics·2015· 34 citedOpen Access
Extensive negative genetic interactions with &lt;i&gt;npl3&lt;/i&gt; Δ connect &lt;i&gt;NPL3&lt;/i&gt; to chromatin biology.
Figshare·2015Open Access
SR protein kinases promote splicing of nonconsensus introns
Nature Structural & Molecular Biology·2015· 44 cited
Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast
PLoS Genetics·2015· 28 citedOpen Access
Present at the creation
RNA·2015Open Access
Genetic interaction analysis of point mutations enables interrogation of gene function at a residue‐level resolution
BioEssays·2014· 9 citedOpen Access
Adventures in time and space
RNA Biology·2014· 48 citedOpen Access
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Frequent Co-authors

Megan Bergkessel(4), Nevan J. Krogan(4), Jeffrey A. Pleiss(4), Paul G. Siliciano(3), David A. Brow(3), Michael Shales(3), Gregg B. Whitworth(3), Sean M. Burgess(3), Christian W. Siebel(3), Corina Maeder(3), Jonathan P. Staley(2), Roy D. Parker(2), Pratima L. Raghunathan(2), Hannes Braberg(2), Gerard Cagney(2), Sean R. Collins(2), Tracy L. Kress(2), Trey Ideker(2), Michio Nomura(2), Wendy V. Gilbert(2)