Elisa Roztocil

University of Rochester Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index938citations86works1.22yr avg
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Research Topics

Protease and Inhibitor Mechanisms(18), Sphingolipid Metabolism and Signaling(14), Protein Kinase Regulation and GTPase Signaling(12), Ophthalmology and Eye Disorders(12), Glaucoma and retinal disorders(11)

Publications85 total

MON-360 Lonigutamab (Anti-IGF-1R Monoclonal Antibody) Reduces IGF-1-Mediated Hyaluronan Production in Thyroid Eye Disease Orbital Fibroblasts
Journal of the Endocrine Society·2025Open Access
Metformin inhibits PDGF signaling to suppress hyaluronan and IL-6 production in Thyroid Eye Disease
2025Open Access
Targeting the Aryl Hydrocarbon Receptor to Attenuate IGF1R Signaling in Thyroid Eye Disease
Thyroid·2025· 2 citedOpen Access
Metformin inhibits PDGFβ signaling to suppress hyaluronan and cytokine production in thyroid eye disease
SSRN Electronic Journal·2025Open Access
Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy
Investigative Ophthalmology & Visual Science·2024· 4 citedOpen Access
TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy
PLoS ONE·2022· 16 citedOpen Access
More than Meets the Eye: The Aryl Hydrocarbon Receptor is an Environmental Sensor, Physiological Regulator and a Therapeutic Target in Ocular Disease
Frontiers in Toxicology·2022· 18 citedOpen Access
Thinking inside the box: Current insights into targeting orbital tissue remodeling and inflammation in thyroid eye disease
Survey of Ophthalmology·2021· 25 citedOpen Access
Investigating the role of circulating microRNAs as potential biomarkers for Thyroid Eye Disease
Investigative Ophthalmology & Visual Science·2021· 1 citedOpen Access
Inhibition of TNF-α and NF-κB decreases epithelial-mesenchymal transition in cigarette smoke-induced proliferative vitreoretinopathy
Investigative Ophthalmology & Visual Science·2021Open Access
Elucidating the role of the aryl hydrocarbon receptor and the insulin-like growth factor 1 receptor in Thyroid Eye Disease orbital fibroblasts.
Investigative Ophthalmology & Visual Science·2021Open Access
Neonatal hyperoxia impairs adipogenesis of bone marrow-derived mesenchymal stem cells and fat accumulation in adult mice
Free Radical Biology and Medicine·2021· 2 citedOpen Access
MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK
Investigative Ophthalmology & Visual Science·2021· 23 citedOpen Access
Activation of the aryl hydrocarbon receptor induces matrix metalloproteinase-1 in thyroid eye disease orbital fibroblasts: implications for anti-scarring therapies
Investigative Ophthalmology & Visual Science·2020Open Access
The aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts
Scientific Reports·2020· 27 citedOpen Access
TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts
Investigative Ophthalmology & Visual Science·2019· 70 citedOpen Access
Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
PLoS ONE·2019· 22 citedOpen Access
The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
PLoS ONE·2019· 16 citedOpen Access
The Aryl Hydrocarbon Receptor and Its Ligands Inhibit Myofibroblast Formation and Activation
American Journal Of Pathology·2016· 49 citedOpen Access
Salinomycin and Other Polyether Ionophores Are a New Class of Antiscarring Agent
Journal of Biological Chemistry·2014· 37 citedOpen Access
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Frequent Co-authors

Mark G. Davies(27), Suzanne M. Nicholl(21), Collynn F. Woeller(14), Steven E. Feldon(13), Christine L. Hammond(8), Irfan I. Galaria(8), W.J. Tanski(7), Allison J. Fegley(5), David L. Gillespie(5), Richard P. Phipps(4), Mithra O. Gonzalez(4), John P. Cullen(4), Andrew M. Bakken(3), Amanda Clark(3), Catherine E. Ovitt(2), Yiping Zou(2), Qi Yan(2), Clinton D. Protack(2), V. Gupta(2), Neil G. Kumar(2)