Jean Paul Vonsattel

Columbia University Irving Medical Center — United States

Neuroscience · Life Sciences

70h-index30.4kcitations229works9.02yr avg
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Research Topics

Genetic Neurodegenerative Diseases(77), Alzheimer's disease research and treatments(62), Neurological disorders and treatments(49), Parkinson's Disease Mechanisms and Treatments(48), Mitochondrial Function and Pathology(45)

Publications210 total

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy
Neuron·2025· 4 citedOpen Access
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord
Acta Neuropathologica·2025· 3 citedOpen Access
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Nature Communications·2025· 8 citedOpen Access
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Nature Communications·2025· 5 citedOpen Access
Amyloid-β predominant Alzheimer’s disease neuropathologic change
Brain·2024· 9 citedOpen Access
Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups
Acta Neuropathologica·2024· 6 citedOpen Access
Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state
Nature Communications·2024· 26 citedOpen Access
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
2024· 4 citedOpen Access
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
Cell stem cell·2024· 23 citedOpen Access
Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups
2024· 2 citedOpen Access
Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state
2023· 3 citedOpen Access
LATE-NC risk alleles (in <i>TMEM106B, GRN</i>, and <i>ABCC9</i> genes) among persons with African ancestry
Journal of Neuropathology & Experimental Neurology·2023· 15 citedOpen Access
Patterns of <scp>TDP</scp>‐43 Deposition in Brains with <scp><i>LRRK2</i> G2019S</scp> Mutations
Movement Disorders·2023· 14 citedOpen Access
Clinical and Pathological Characterization of VPS16 Dystonia (P11-11.005)
Neurology·2023· 3 cited
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
Nature Communications·2022· 66 citedOpen Access
Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository
Journal of Neuropathology & Experimental Neurology·2022· 31 citedOpen Access
Parkinson's Progression Markers Initiative brain autopsy program
Parkinsonism & Related Disorders·2022· 8 cited
Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism
2022· 2 citedOpen Access
Clinicopathological correlates of pyramidal signs in multiple system atrophy
Annals of Clinical and Translational Neurology·2022· 6 citedOpen Access
Histopathology of the Cerebellar Cortex in Essential Tremor and Other Neurodegenerative Motor Disorders: Comparative Analysis of 311 Brains (S32.007)
Neurology·2022
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Frequent Co-authors

Richard H. Myers(9), John Q. Trojanowski(7), Dennis W. Dickson(7), Lawrence S. Honig(7), Marla Gearing(6), Neill R. Graff‐Radford(6), Julie A. Schneider(5), Thomas G. Beach(5), Eliezer Masliah(5), Charles L. White(5), James F. Gusella(5), Bradley F. Boeve(5), Bernardino Ghetti(5), Elan D. Louis(5), Steven E. Arnold(4), Bradley T. Hyman(4), Ian R. Mackenzie(4), Juan C. Troncoso(4), Marcy E. MacDonald(4), Edward D. Bird(4)