Hiroyuki Utsumi

Mitsubishi Group (Japan) — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index969citations29works0.02yr avg
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Research Topics

Sphingolipid Metabolism and Signaling(4), T-cell and B-cell Immunology(3), Chronic Kidney Disease and Diabetes(3), Barrier Structure and Function Studies(3), Liver Disease Diagnosis and Treatment(2)

Publications29 total

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models
Journal of Immunology Research·2019· 19 citedOpen Access
Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells
PLoS ONE·2019· 39 citedOpen Access
Pathological characterization and morphometric analysis of hepatic lesions in SHRSP5/Dmcr, an experimental non‐alcoholic steatohepatitis model, induced by high‐fat and high‐cholesterol diet
International Journal of Experimental Pathology·2016· 21 citedOpen Access
Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction
Molecular Medicine Reports·2015· 38 citedOpen Access
IL-17–Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions
The Journal of Immunology·2015· 40 cited
Quantitative analysis of markers of podocyte injury in the rat puromycin aminonucleoside nephropathy model
Experimental and Toxicologic Pathology·2014· 20 cited
Automated image analysis of a glomerular injury marker desmin in spontaneously diabetic Torii rats treated with losartan
Journal of Endocrinology·2014· 52 citedOpen Access
S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1
International Immunology·2013· 27 cited
The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice
European Journal of Pharmacology·2013· 49 cited
Automated recognition and quantification of pancreatic islets in Zucker diabetic fatty rats treated with exendin-4
Journal of Endocrinology·2012· 25 citedOpen Access
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorganic & Medicinal Chemistry·2012· 148 citedOpen Access
Expression of Vascular Endothelial Growth Factor (VEGF) Associated with Histopathological Changes in Rodent Models of Osteoarthritis
Journal of Toxicologic Pathology·2011· 23 citedOpen Access
Evaluation of gene expression related to hepatic cell maturation and differentiation in a chemically induced mouse hepatoblastoma cell line
Experimental and Molecular Pathology·2007· 1 cited
Genomic biomarker for cholestasis(Proceedings of the 32nd Annual Meeting)
The Journal of Toxicological Sciences·2005
P6-06 The Induction of mRNA related with hepatic injury response to oxidative stimuli in hepatocytes and non-parenchymal cells(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
The Journal of Toxicological Sciences·2004
One-Step RT-PCR without Initial RNA Isolation Step for Laser-Microdissected Tissue Sample
Journal of Veterinary Medical Science·2003· 14 citedOpen Access
Barrier function of microvessels and roles of glial cell line-derived neurotrophic factor in the rat testis
Medical Electron Microscopy·2002· 24 cited
Expression of GFRα-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB
American Journal of Physiology-Cell Physiology·2000· 60 cited
Expression of Receptors for Glial Cell Line-derived Neurotrophic Factor (GDNF) and Neurturin in the Inner Blood-retinal Barrier of Rats.
Cell Structure and Function·2000· 59 citedOpen Access
COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 6)2-AND 4-WEEKS ADMINISTRATION STUDY OF HALOPERIDOL
The Journal of Toxicological Sciences·2000· 4 citedOpen Access
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Frequent Co-authors

Atsushi Fukunari(7), Tetsuhiro Kakimoto(6), Hideki Chiba(4), Hirotoshi Tobioka(4), Yasuhiro Kamimura(4), Kunio Sugahara(4), Y Igarashi(3), Michio Mori(3), Norimasa Sawada(3), Yasuhiro Maeda(3), Hirotoshi Kataoka(3), Kana Takemoto(3), Shin Kohge(3), Shiro Takagi(3), Masaki Takeuchi(3), Shin‐ichi Ishii(2), Satoko Kiuchi(2), Tomoko Gotoh(2), Kinya Okada(2), Keisuke Fujitaka(2)