E G Krebs

Brigham and Women's Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index7.7kcitations35works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(7), Protein Structure and Dynamics(5), Chemical Synthesis and Analysis(5), Cancer, Hypoxia, and Metabolism(4), Protein Tyrosine Phosphatases(4)

Publications35 total

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes·1999· 246 cited
Protein phosphorylation and signal transduction
Cellular & Molecular Biology Letters·1998
A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
Molecular Biology of the Cell·1997· 61 citedOpen Access
Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.
Proceedings of the National Academy of Sciences·1996· 140 citedOpen Access
Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells.
Proceedings of the National Academy of Sciences·1995· 76 cited
Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells.
Journal of Biological Chemistry·1994· 116 citedOpen Access
Fibroblast growth factor, but not activin, is a potentactivator of mitogen-activated protein kinase in Xenopusexplants.
Proceedings of the National Academy of Sciences·1994· 39 citedOpen Access
Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues.
Proceedings of the National Academy of Sciences·1993· 36 citedOpen Access
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
Journal of Biological Chemistry·1992· 372 citedOpen Access
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
Journal of Biological Chemistry·1991· 1.3k citedOpen Access
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.
Proceedings of the National Academy of Sciences·1991· 343 citedOpen Access
Activation of protein kinases in wild type and phorbol ester resistant el4 thymoma cells
1991
The Albert Lasker Medical Awards. Role of the cyclic AMP-dependent protein kinase in signal transduction
JAMA·1989· 51 cited
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
Proceedings of the National Academy of Sciences·1989· 276 citedOpen Access
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.
Proceedings of the National Academy of Sciences·1989· 317 citedOpen Access
Activation of casein kinase II in response to insulin and to epidermal growth factor.
Proceedings of the National Academy of Sciences·1987· 300 citedOpen Access
Agents that elevate cAMP levels in platelets decrease thrombin binding.
Journal of Biological Chemistry·1987· 66 citedOpen Access
Mitogen responsive ribosomal s 6 kinase from 3t3 d 1 cells
Federation Proceedings·1986
Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences·1986· 202 citedOpen Access
Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex
Journal of Neuroscience·1985· 42 citedOpen Access
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Frequent Co-authors

Kenneth A. Walsh(4), Rony Seger(3), Natalie G. Ahn(3), Edmond H. Fischer(3), David B. Glass(3), Jackie R. Vandenheede(3), Koji Takio(3), Joseph A. Beavo(2), Melanie H. Cobb(2), D E Cool(2), Harry Charbonneau(2), Hagit Eldar-Finkelman(2), Bruce E. Kemp(2), John D. Scott(2), E H Fischer(2), Ramji L. Khandelwal(2), Stephen B. Smith(2), Koiti Titani(2), Jean S. Campbell(2), Lee M. Graves(2)