Tomi K. Sawyer

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index10.2kcitations279works8.52yr avg
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Research Topics

Chemical Synthesis and Analysis(84), Protein Kinase Regulation and GTPase Signaling(47), Click Chemistry and Applications(44), Computational Drug Discovery Methods(27), Receptor Mechanisms and Signaling(25)

Publications278 total

Author Correction: Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Nature Communications·2025Open Access
Design, Structure–Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists
Molecules·2024· 1 citedOpen Access
Molecular Mechanism of P53 Peptide Permeation through Lipid Membranes from Solid-State NMR Spectroscopy and Molecular Dynamics Simulations
Journal of the American Chemical Society·2024· 4 cited
Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice
Journal of Clinical Investigation·2024· 9 citedOpen Access
The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models
Frontiers in Behavioral Neuroscience·2024· 3 citedOpen Access
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Nature Communications·2024· 34 citedOpen Access
Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents
2023· 4 citedOpen Access
Aqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment
Journal of Controlled Release·2023· 11 cited
Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development
Journal of Medicinal Chemistry·2023· 110 citedOpen Access
Data from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 2A (Src527F panels) from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 3C from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 3C from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 2A (SrcMF panels) from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 2A (Src527F panels) from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Supplementary video for Fig. 2A (SrcMF panels) from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Data from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
2023Open Access
Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
2023· 2 citedOpen Access
Peptide Drug Discovery<i>Raison d’Etre</i>: Engineering Mindset, Design Rules and Screening Tools
ACS symposium series·2022· 7 cited
Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
Cancer Research·2022· 1 citedOpen Access
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Frequent Co-authors

William C. Shakespeare(15), Chester A. Metcalf(13), David C. Dalgarno(12), Raji Sundaramoorthi(10), Victor J. Hruby(9), Mac E. Hadley(9), Yihan Wang(8), Regine S. Bohacek(8), John D. Iuliucci(5), Jeffrey Keats(4), Brian C. Wilkes(4), Marie Rose van Schravendijk(4), Gary E. Gallick(4), Victor M. Rivera(3), Scott Wardwell(3), J. T. Snodgrass(3), Michael W. Deininger(3), Brian Druker(3), Tim Clackson(3), Douglas J. Staples(3)