Michael S. Kilberg

University of Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index5.9kcitations51works9.02yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(33), RNA regulation and disease(21), Pancreatic function and diabetes(9), Amino Acid Enzymes and Metabolism(9), RNA Research and Splicing(5)

Publications51 total

Assessing cancer therapeutic efficacy in vivo using [ <sup>2</sup> H <sub>7</sub> ]glucose deuterium metabolic imaging
Science Advances·2025· 9 citedOpen Access
Sequencing of Argonaute-bound miRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a
2021· 4 citedOpen Access
The role of asparagine synthetase on nutrient metabolism in pancreatic disease
Pancreatology·2020· 17 cited
Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2018· 37 cited
Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms·2018· 20 cited
Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
Trends in Endocrinology and Metabolism·2017· 598 citedOpen Access
Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells
Oncotarget·2017· 18 citedOpen Access
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element
Journal of Biological Chemistry·2015· 213 citedOpen Access
MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2014· 23 citedOpen Access
A Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK)-dependent Transcriptional Program Controls Activation of the Early Growth Response 1 (EGR1) Gene during Amino Acid Limitation
Journal of Biological Chemistry·2014· 31 citedOpen Access
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
Molecular Biology of the Cell·2013· 226 citedOpen Access
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Nature Cell Biology·2013· 1.6k cited
Asparagine synthetase: regulation by cell stress and involvement in tumor biology
American Journal of Physiology-Endocrinology and Metabolism·2013· 237 citedOpen Access
Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response
Physiological Genomics·2012· 24 citedOpen Access
Dynamic changes in genomic histone association and modification during activation of the <i>ASNS</i> and <i>ATF3</i> genes by amino acid limitation
Biochemical Journal·2012· 10 citedOpen Access
ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation
Journal of Biological Chemistry·2012· 60 citedOpen Access
The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells
Advances in Nutrition·2012· 139 citedOpen Access
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells
Physiological Genomics·2010· 53 citedOpen Access
C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene
Journal of Biological Chemistry·2008· 178 citedOpen Access
Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway
Biochemical Journal·2008· 54 citedOpen Access
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Frequent Co-authors

Jixiu Shan(13), Yuan‐Xiang Pan(7), Can Zhong(7), Elizabeth E. Dudenhausen(6), Chin Chen(6), Mukundh Balasubramanian(5), Fai Siu(4), Hong Chen(4), Lingchen Fu(4), Halvor N. Christensen(4), Mary E. Handlogten(4), Ione Parra Barbosa‐Tessmann(3), Altin Gjymishka(3), Jaclyn N. Hayner(3), Nan Su(2), Sheldon M. Schuster(2), Harry S. Nick(2), Michelle M. Thiaville(2), Maria-Cecilia Lopez(2), Henry V. Baker(2)