J. Christopher Gorski

Mylan (United States) — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

28h-index3.0kcitations59works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(23), Drug Transport and Resistance Mechanisms(11), Pharmacological Effects and Toxicity Studies(7), Liver Disease Diagnosis and Treatment(6), Drug-Induced Hepatotoxicity and Protection(5)

Publications59 total

The Comparative Bioavailability of Fluticasone and Azelastine Delivered as a Single Fixed Dose Combination (MP-AzeFlu) in Comparison to Two Different Formulations of Azelastine and Fluticasone Propionate Following Intranasal Administration in Healthy Chinese Volunteers
Journal of Asthma and Allergy·2023· 1 citedOpen Access
Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping
Drug metabolism and drug interactions·2013· 8 cited
Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin
European Journal of Clinical Pharmacology·2012· 30 citedOpen Access
Assessment of oral midazolam limited sampling strategies to predict area under the concentration time curve (AUC) during cytochrome P450 (CYP) 3A baseline, inhibition and induction or activation
International Journal of Clinical Pharmacology and Therapeutics·2010· 9 cited
Drug-induced QT Prolongation in Cirrhotic Patients With Transjugular Intrahepatic Portosystemic Shunt
Journal of Clinical Gastroenterology·2010· 14 cited
Effects of Commonly Administered Agents and Genetics on Nebivolol Pharmacokinetics: Drug-Drug Interaction Studies
The Journal of Clinical Pharmacology·2010· 38 cited
Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin
Drug Metabolism and Disposition·2009· 78 citedOpen Access
Semiphysiologically Based Pharmacokinetic Models for the Inhibition of Midazolam Clearance by Diltiazem and Its Major Metabolite
Drug Metabolism and Disposition·2009· 95 cited
Altered First-Pass Effects in a Liver Transplant Recipient Explained Intraindividual Variation in Calcineurin Inhibitor Concentrations: A Case Report
Transplantation Proceedings·2008· 1 cited
Severe Impairment of Endothelial Function with the HIV-1 Protease Inhibitor Indinavir is not Mediated by Insulin Resistance in Healthy Subjects
Cardiovascular Toxicology·2008· 30 citedOpen Access
Interaction between midazolam and clarithromycin in the elderly
British Journal of Clinical Pharmacology·2007· 49 citedOpen Access
Drug Interactions with St. John's Wort and Echinacea
Drugs and the pharmaceutical sciences·2006
Drug Interactions with St. John’s Wort and Echinacea
2006
Insulin sensitivity is preserved despite disrupted endothelial function
American Journal of Physiology-Endocrinology and Metabolism·2006· 17 cited
STOCHASTIC PREDICTION OF CYP3A-MEDIATED INHIBITION OF MIDAZOLAM CLEARANCE BY KETOCONAZOLE
Drug Metabolism and Disposition·2006· 74 cited
Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer
Clinical Cancer Research·2006· 121 citedOpen Access
PIII-55Prediction of clarithromycin nonlinear pharmacokinetics and its interaction with midazolam using a physiologically-based pharmacokinetic model
Clinical Pharmacology & Therapeutics·2006
Indinavir impairs endothelial function in healthy HIV-negative men
American Heart Journal·2005· 92 cited
Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption
Hepatology·2005· 60 citedOpen Access
DEXTROMETHORPHAN TO DEXTRORPHAN URINARY METABOLIC RATIO DOES NOT REFLECT DEXTROMETHORPHAN ORAL CLEARANCE
Drug Metabolism and Disposition·2005· 37 cited
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Frequent Co-authors

Stephen D. Hall(23), Naga Chalasani(7), Mitchell A. Hamman(6), Amar G. Pinto(5), David R. Jones(4), David A. Flockhart(4), Steven Wrighton(4), Sara K. Quinney(4), Zeruesenay Desta(3), Juan Maya(3), Lang Li(3), D. Craig Brater(3), E Czestochowska(3), Zaiqi Wang(2), Ali Asghar(2), David Jones(2), Sudha S. Shankar(2), Helmut O. Steinberg(2), Aroonrut Lucksiri(2), Barbara D. Haehner(2)