John H. Kehne

National Institutes of Health — United States

Neuroscience · Life Sciences

34h-index3.9kcitations83works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(28), Neurotransmitter Receptor Influence on Behavior(27), Pain Mechanisms and Treatments(11), Stress Responses and Cortisol(11), Receptor Mechanisms and Signaling(10)

Publications83 total

Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP)
Neurochemical Research·2017· 122 cited
The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)
Neurochemical Research·2017· 140 citedOpen Access
Oro-gastric (og) administration of NGD CRF<sub>1</sub> antagonist, NGD 98-2 or NGD 9002 reduces acute water avoidance stress (WAS)-induced stimulation of colonic propulsive motor function in rats.
Figshare·2015Open Access
The Newly Developed CRF1-Receptor Antagonists, NGD 98-2 and NGD 9002, Suppress Acute Stress-Induced Stimulation of Colonic Motor Function and Visceral Hypersensitivity in Rats
PLoS ONE·2013· 30 citedOpen Access
Electrophysiological evidence for rapid 5-HT1A autoreceptor inhibition by vilazodone, a 5-HT1A receptor partial agonist and 5-HT reuptake inhibitor
European Journal of Pharmacology·2013· 26 citedOpen Access
Targeting memory processes with drugs to prevent or cure PTSD
Expert Opinion on Investigational Drugs·2012· 53 citedOpen Access
GABA and Schizophrenia
2012· 3 cited
The Pharmacokinetics and Pharmacodynamics of Zaleplon Delivered as a Thermally Generated Aerosol in a Single Breath to Volunteers
The Journal of Clinical Pharmacology·2012· 5 cited
Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo‐controlled clinical trial with inhaled loxapine
Bipolar Disorders·2012· 124 cited
Discovery of <i>N</i>-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine <b>59</b> (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1) Receptor Antagonist
Journal of Medicinal Chemistry·2011· 13 citedOpen Access
Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine
The British Journal of Psychiatry·2011· 153 citedOpen Access
Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals
Psychopharmacology·2010· 3 citedOpen Access
Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models
Pharmacology & Therapeutics·2010· 103 cited
The dopamine D2 receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with l-dopa
Journal of Neural Transmission·2009· 15 cited
Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans
Journal of Sleep Research·2009· 30 cited
CRF1 receptor antagonists: treatment of stress-related disorders
Drug Discovery Today Therapeutic Strategies·2008· 6 cited
D2 Receptor Partial Agonists: Treatment of CNS Disorders of Dopamine Function
Current Topics in Medicinal Chemistry·2008· 20 cited
2-Arylpyrimidines: Novel CRF-1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 10 citedOpen Access
The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 22 citedOpen Access
Editorial [Hot Topic: Depression (Part 2) (Guest Editors: Ronald S. Duman and John H. Kehne)]
CNS & Neurological Disorders - Drug Targets·2007· 5 cited
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Frequent Co-authors

Timothy C. McCloskey(12), Vicki L. Taylor(6), Michael T. Davis(6), Gina M. Fadayel(5), C J Schmidt(5), James V. Cassella(5), Yaw Senyah(4), Boyd L. Harrison(4), Michael G. Palfreyman(4), Mark W. Dudley(4), Robert Padich(4), H. Steve White(4), Diane C. Hoffman(4), John M. Kane(4), Robert Frank(3), Barry W. Siegel(3), S.M. Sorensen(3), T M Humphreys(3), Bruce M. Baron(3), Christopher J. Schmidt(3)