Gene C. Ness

Medicine · Health Sciences

31h-index3.4kcitations94works0.02yr avg
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Research Topics

Cholesterol and Lipid Metabolism(37), Peroxisome Proliferator-Activated Receptors(25), Plant biochemistry and biosynthesis(19), Lipoproteins and Cardiovascular Health(13), Cancer, Lipids, and Metabolism(13)

Publications94 total

7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome
UNC Libraries·2020Open Access
Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2015· 38 cited
Distribution of the LDL receptor within clathrin-coated pits and caveolae in rat and human liver
Biochemical and Biophysical Research Communications·2014· 16 cited
Inhibitory roles of protein kinase B and peroxisome proliferator-activated receptor gamma coactivator on hepatic HMG-CoA reductase promoter activity
Advances in Bioscience and Biotechnology·2013Open Access
Using in vivo electroporation to identify hepatic LDL receptor promoter elements and transcription factors mediating activation of transcription by T3
Applied & Translational Genomics·2012· 2 citedOpen Access
Activation of transcription of hepatic HMG‐CoA reductase by insulin requires tristetraprolin
The FASEB Journal·2012
Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin
Biochemical and Biophysical Research Communications·2012· 6 cited
Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter
Atherosclerosis·2011· 37 citedOpen Access
Mechanism of Resistance to Dietary Cholesterol
Journal of Lipids·2011· 29 citedOpen Access
Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements
Molecular and Cellular Endocrinology·2010· 197 cited
Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone
Journal of Biological Chemistry·2009· 65 citedOpen Access
In vivo identification of promoter elements and transcription factors mediating activation of hepatic HMG-CoA reductase by T3
Biochemical and Biophysical Research Communications·2009· 16 citedOpen Access
Increased Expression of Hepatic Scavenger Receptor B 1 and Apo A‐I in Streptozotocin‐induced Diabetic Rats
The FASEB Journal·2009
In Vivo Identification of Multiple Response Elements Mediating Thyroid Hormone Stimulation of Hepatic HMG‐CoA Reductase Transcription
The FASEB Journal·2009
Technological advances in the study of HLA-DRA promoter regulation: Extending the functions of CIITA, Oct-1, Rb, and RFX
Acta Biochimica et Biophysica Sinica·2009· 2 cited
Microarray Analysis Reveals Hepatic Adaptive Responses to Excess Dietary Cholesterol
The FASEB Journal·2008
In vivo identification of response elements mediating thyroid hormone stimulation of hepatic HMG‐CoA reductase transcription
The FASEB Journal·2008
Mammalian Sirtuin 1 Is Involved in the Protective Action of Dietary Saturated Fat against Alcoholic Fatty Liver in Mice
Journal of Nutrition·2008· 91 cited
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
American Journal of Physiology-Gastrointestinal and Liver Physiology·2008· 214 cited
Activation of the hepatic LDL receptor promoter by thyroid hormone
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2007· 123 cited
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Frequent Co-authors

Dayami Lopez(9), Christopher M. Chambers(8), Carl M. Nepokroeff(6), M.R. Lakshmanan(6), John W. Porter(6), Richard E. Dugan(5), Sarah Shefer(5), Gerald Salen(5), Guorong Xu(4), Ashok K. Batta(4), William R. Lagor(4), Karen Gertz(4), Melissa I. Niesen(3), G. Stephen Tint(3), Laura C. Pendleton(3), Lindsey R. Boone(3), Mary H. Moffler(3), Min You(2), Xiaomei Liang(2), Joanne M. Ajmo(2)