Joseph F. Kelleher

Augusta University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.6kcitations58works1.02yr avg
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Research Topics

Hedgehog Signaling Pathway Studies(17), Microtubule and mitosis dynamics(8), Epigenetics and DNA Methylation(5), Chromosomal and Genetic Variations(4), Glycosylation and Glycoproteins Research(4)

Publications58 total

Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke
Frontiers in Neurology·2025· 1 citedOpen Access
Supplemental information from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Table S2 from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Table S1 from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Data from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Supplemental information from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Table S1 from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Data from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Table S2 from A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors
2023Open Access
Supplemental Methods, Figures 1 - 8, Tables 1 - 2 from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
2023Open Access
Data from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
2023Open Access
Data from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
2023Open Access
Supplemental Methods, Figures 1 - 8, Tables 1 - 2 from RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway–Dependent Tumors
2023Open Access
Abstract 5222: Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts <i>in vivo</i>
Cancer Research·2020· 1 cited
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
Stem Cell Reports·2019· 67 citedOpen Access
Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition
Cancer Research·2019· 2 cited
Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition
Experimental and Molecular Therapeutics·2019
KYM‐001, A FIRST‐IN‐CLASS ORAL IRAK4 PROTEIN DEGRADER, INDUCES TUMOR REGRESSION IN XENOGRAFT MODELS OF MYD88‐MUTANT ABC DLBCL ALONE AND IN COMBINATION WITH BTK INHIBITION
Hematological Oncology·2019· 5 cited
Modelling the vasculature of the genetic stroke disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients in vitro using induced pluripotent stem cells (iPSCs)
Research Portal (King's College London)·2019
Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma
Blood·2018· 3 cited
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Frequent Co-authors

Ekaterina Pak(12), Rosalind A. Segal(12), Marion Dorsch(11), Tatyana Ponomaryov(11), Kimberly J. Ornell(11), Stefan Peukert(9), Maria F. Pazyra‐Murphy(9), Xu Wu(8), Ethan L. MacKenzie(8), Emily J. Chadwick(8), Silvia Buonamici(7), Juliet Williams(7), Anthony Vattay(7), Jing Yuan(7), Xuesong Zhao(7), Ribo Guo(6), Shifeng Pan(6), Markus Warmuth(6), Arun Ramamurthy(6), Karen Miller‐Moslin(5)