Martin I. Freed

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index5.5kcitations55works1.02yr avg
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Research Topics

Peroxisome Proliferator-Activated Receptors(20), Diabetes Treatment and Management(16), Metabolism, Diabetes, and Cancer(11), Diabetes, Cardiovascular Risks, and Lipoproteins(5), Drug Transport and Resistance Mechanisms(5)

Publications53 total

The Role of Endothelin in Human Disease: Implications and Potential Therapeutic Intervention
2024· 1 cited
Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease
Science Translational Medicine·2016· 72 cited
Prospective evaluation of pulmonary function in Parkinson's disease patients with motor fluctuations
International Journal of Neuroscience·2016· 20 citedOpen Access
A randomized trial of inhaled levodopa (CVT‐301) for motor fluctuations in Parkinson's disease
Movement Disorders·2016· 89 citedOpen Access
Effect of Patient Characteristics on Motor Function in Response to 35-50 mg of Inhaled Levodopa (CVT-301) in Patients with Parkinson’s Disease: Results from a Phase 2b Study (P5.372)
Neurology·2016
Rapid Levodopa Augmentation Following Inhaled CVT-301 Results in Rapid Improvement in Motor Response When Administered to PD Patients in the OFF State (S7.007)
Neurology·2014· 9 cited
Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans
Journal of Pharmacology and Experimental Therapeutics·2013· 219 cited
Abstract 1745: Translational medicine enables rapid early clinical development of AVL-292, a highly selective, orally available inhibitor of Bruton's tyrosine kinase, in a phase 1b clinical trial
Cancer Research·2012· 4 cited
A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe
Diabetic Medicine·2006· 55 cited
Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria
Journal of Hypertension·2006· 98 cited
Obesity Is a Major Determinant of the Association of C-Reactive Protein Levels and the Metabolic Syndrome in Type 2 Diabetes
Diabetes·2006· 189 citedOpen Access
Improving Metabolic Control Leads to Better Working Memory in Adults With Type 2 Diabetes
Diabetes Care·2006· 287 cited
Effect of early addition of rosiglitazone to sulphonylurea therapy in older type 2 diabetes patients (>60 years): the Rosiglitazone Early vs. SULphonylurea Titration (RESULT) study
Diabetes Obesity and Metabolism·2005· 61 citedOpen Access
Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe
Diabetes·2004· 193 citedOpen Access
Rosiglitazone, But Not Glyburide, Reduces Circulating Proinsulin and the Proinsulin:Insulin Ratio in Type 2 Diabetes
The Journal of Clinical Endocrinology & Metabolism·2004· 54 citedOpen Access
Pharmacokinetics of Rosiglitazone in Patients with Varying Degrees of Renal Insufficiency
The Journal of Clinical Pharmacology·2003· 78 cited
Rosiglitazone reduces urinary albumin excretion in type II diabetes
Journal of Human Hypertension·2003· 240 cited
Prevalence of microalbuminuria in recently diagnosed Type 2 diabetes mellitus and its relationship to non-traditional risk factors: observations from the ADOPT study
Oxford University Research Archive (ORA) (University of Oxford)·2003· 1 cited
Levels of beta-cell dysfunction and insulin resistance differ between Europeans and North Americans with recently-diagnosed diabetes in the ADOPT study
Oxford University Research Archive (ORA) (University of Oxford)·2003· 1 cited
A Comparison of the Effects of Rosiglitazone and Glyburide on Cardiovascular Function and Glycemic Control in Patients With Type 2 Diabetes
Diabetes Care·2002· 254 cited
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Frequent Co-authors

Diane K. Jorkasky(16), Mark Heise(8), Ann K. Miller(6), Bernard E. Ilson(6), Steven M. Haffner(5), Steven E. Kahn(5), Lisa E. Porter(5), Steven C. Boike(5), Névine Zariffa(5), Wayde M. Weston(4), Giancarlo Viberti(4), Bernard Zinman(4), Rury R. Holman(4), John M. Lachin(4), Robert A. Blum(4), David E. Martin(4), Jo Dole(3), Rita Patwardhan(3), William H. Herman(3), Nigel C. Jones(3)