J. A. Hinson

University of Arkansas for Medical Sciences — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

20h-index1.6kcitations33works0.02yr avg
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Research Topics

Drug-Induced Hepatotoxicity and Protection(18), Drug Transport and Resistance Mechanisms(8), Pharmacogenetics and Drug Metabolism(7), Eicosanoids and Hypertension Pharmacology(5), Sulfur Compounds in Biology(4)

Publications33 total

New insights into the mechanisms of acetaminophen toxicity
Toxicology Letters·2010· 1 cited
Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose
Clinical Pharmacology & Therapeutics·2008· 72 citedOpen Access
784 Serum acetaminophen adducts reliably distinguish acetaminophen toxicity from other causes of acute liver failure
Hepatology·2003· 3 cited
Western Blot Analysis for Nitrotyrosine Protein Adducts in Livers of Saline-Treated and Acetaminophen-Treated Mice
Toxicological Sciences·2000· 77 cited
Biomarkers of acetaminophen (APAP) toxicity in pediatric patients
Clinical Pharmacology & Therapeutics·1999
Antigenic biomarker identification of acetaminophen (APAP) hepatotoxicity (HT) in children
Clinical Pharmacology & Therapeutics·1999
Immunochemical comparison of 3'-hydroxyacetanilide and acetaminophen binding in mouse liver.
PubMed·1998· 18 cited
Small cell lung cancer
CA A Cancer Journal for Clinicians·1993· 21 citedOpen Access
Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on Proteins
The Annual Review of Pharmacology and Toxicology·1992· 136 cited
Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
PubMed·1991· 179 citedOpen Access
Quantification of an antigen biomarker of paracetamol toxicity [3-(cystein-s-yl)paracetamol protein adduct (3-cys-P)] in overdose patients: Correlation with toxicity
Journal of Hepatology·1991
Acetaminophen-induced alterations in pancreatic β cells and serum insulin concentrations in B6C3F1 mice
Toxicology and Applied Pharmacology·1990· 6 cited
Mechanism of paracetamol toxicity
The Lancet·1990· 60 cited
Utility of solution electrochemistry mass spectrometry for investigation the formation and detection of biologically important conjugates of acetaminophen
Journal of Chromatography A·1989· 77 cited
Pretreatment with mixed‐function oxidase inducers increases the sensitivity of the hepatocyte/DNA repair assay
Environmental and Molecular Mutagenesis·1989· 26 cited
The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study
Archives of Biochemistry and Biophysics·1988· 204 cited
Direct analysis of rat bile for acetaminophen and two of its conjugated metabolites via thermospray liquid chromatography/mass spectrometry
Journal of Mass Spectrometry·1987· 25 cited
Fast atom bombardment mass spectrometry and fast atom bombardment mass spectrometry/mass spectrometry of three glutathione conjugates of acetaminophen
Journal of Mass Spectrometry·1987· 14 cited
Mechanisms of acetaminophen oxidation to N-acetyl-P-benzoquinone imine by horseradish peroxidase and cytochrome P-450.
Journal of Biological Chemistry·1987· 105 citedOpen Access
The 1- and 2-electron oxidation of acetaminophen catalyzed by prostaglandin H synthase.
Journal of Biological Chemistry·1987· 82 citedOpen Access
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Frequent Co-authors

L R Pohl(7), Dean W. Roberts(5), David W. Potter(5), R. J. Highet(5), Robert W. Benson(4), Neil R. Pumford(4), Terrence J. Monks(4), Laura P. James(4), Thomas J. Bucci(3), T J Monks(3), J.R. Mitchell(3), Jackson O. Lay(3), Sidney D. Nelson(2), Alan Warbritton(2), Tammie A. McRae(2), Walter A. Korfmacher(2), J R Gillette(2), Kristoffer Dalhoff(2), Steffen Loft(2), Henrik E. Poulsen(2)