Pierre Lainée

Sanofi (France) — France

Medicine · Health Sciences

11h-index433citations53works1.02yr avg
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Research Topics

Cardiac electrophysiology and arrhythmias(18), Ion channel regulation and function(9), Animal testing and alternatives(6), Cardiac Imaging and Diagnostics(5), Cardiovascular Function and Risk Factors(5)

Publications53 total

Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species
Journal of Pharmacological and Toxicological Methods·2025
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies
Journal of Pharmacological and Toxicological Methods·2025· 2 cited
Recommendations on the measurement of electrocardiogram and hemodynamic parameters in restrained non-rodent species in regulatory safety assessment studies
Journal of Pharmacological and Toxicological Methods·2025· 1 cited
Activity in Group-Housed Home Cages of Mice as a Novel Preclinical Biomarker in Oncology Studies
Cancers·2023· 4 citedOpen Access
Pharmacological Validation of a Simplified Cardiorespiratory Safety Procedure in Non-Human Primates Using Non-Invasive Jacketed External Telemetry (JET)
Journal of Pharmacological and Toxicological Methods·2017
Functional Cardiac Safety Evaluation of Novel Therapeutics
Methods and principles in medicinal chemistry·2015· 2 cited
Contributors
Elsevier eBooks·2015
Functional Assessments in Nonhuman Primate Toxicology Studies to Support Drug Development
Elsevier eBooks·2015· 1 cited
Effects of monocarboxylate transporter 1 (MCT1) inhibition on cardiac function under ischaemic conditions: A comparison between rat and guinea-pig Langendorff hearts
Toxicology Letters·2014
Functional assessments in repeat-dose toxicity studies: the art of the possible
Toxicology Research·2013· 56 cited
Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction
American Heart Journal·2012· 22 citedOpen Access
Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment
Toxicology and Applied Pharmacology·2012· 17 cited
A literature-based analysis of cardiovascular adverse events impacting on drug development
Journal of Pharmacological and Toxicological Methods·2012· 9 cited
A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeys
Journal of Pharmacological and Toxicological Methods·2012
Heart rate dependent potentiation of QRS prolongations can be detected in standard dog telemetry studies
Journal of Pharmacological and Toxicological Methods·2012
External telemetry significantly improves ECG assessment in Nonhuman Primates (NHP) over standard methods
Journal of Pharmacological and Toxicological Methods·2012· 2 cited
Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry method
Journal of Pharmacological and Toxicological Methods·2012· 5 cited
Cardiac contractility assessment: A case study with clear impact and relevance of preclinical data
Journal of Pharmacological and Toxicological Methods·2012· 2 cited
Assessment of left ventricular dP/dtmax in telemetry studies: Essential or excessive?
Journal of Pharmacological and Toxicological Methods·2012· 3 cited
Assessment of DeltaT50, a clinical biomarker of QT variability in preclinical dog telemetry studies
Journal of Pharmacological and Toxicological Methods·2012
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Frequent Co-authors

Jean‐Pierre Valentin(22), Matthew Skinner(8), Jackie Moors(5), Annie Delaunois(5), Hugo M. Vargas(5), Helen Prior(5), J Weissenburger(4), F. Chézalviel(4), G Motté(4), G Cheymol(4), Lorna Ewart(4), Karen Philp(4), Anne‐Marie Bétat(4), Guillaume Froget(4), Roy Forster(4), O Ertzbischoff(3), Samantha Borland(3), Jean‐Pierre Valentin(3), Philip Janiak(3), Jean‐Pierre Bidouard(3)