A. Thomas Look

Dana-Farber Cancer Institute — United States

Medicine · Health Sciences

30h-index3.3kcitations52works0.02yr avg
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Research Topics

Acute Lymphoblastic Leukemia research(16), Neuroblastoma Research and Treatments(9), Acute Myeloid Leukemia Research(8), Cancer-related Molecular Pathways(6), Chronic Lymphocytic Leukemia Research(6)

Publications52 total

Abstract 3450: Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors
Cancer Research·2020
Targeting Notch Pathways
2019
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
Data Archiving and Networked Services (DANS)·2016· 15 citedOpen Access
Animal Models
Elsevier eBooks·2015
SNP array analysis in hematologic malignancies: avoiding false discoveries
Blood·2010· 94 citedOpen Access
A putative stemness biomarker gene set suggests γ-secretase inhibitor targets self-renewal and pluripotency programs in tumors
Clinical Cancer Research·2008
Alu elements mediate <i>MYB</i> gene tandem duplication in human T-ALL
The Journal of Experimental Medicine·2007· 94 citedOpen Access
Molecular genetics of acute lymphoblastic leukemia
Cambridge University Press eBooks·2006· 16 cited
O22: A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia
European Journal of Medical Genetics·2005
State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: Summary report of workshop at the First International Symposium on childhood and adolescent non‐Hodgkin lymphoma, April 9, 2003, New York City, NY
Pediatric Blood & Cancer·2005· 19 cited
Evidence for an age cut-off greater than 365 days for neuroblastoma risk group stratification in the Children’s Oncology Group (COG)
Journal of Clinical Oncology·2005· 2 cited
A phase I study of decitabine (DCT) in combination with doxorubicin (DOX) and cyclophosphamide (CTX) in the treatment of relapsed or refractory solid tumors: A Children’s Oncology Group Study
Journal of Clinical Oncology·2005· 2 cited
IL-7–dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL
Blood·2003· 44 citedOpen Access
Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors
Molecular and Cellular Biology·2001· 207 citedOpen Access
Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study
Neoplasia·2001· 106 citedOpen Access
Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family.
International Journal of Molecular Medicine·2000· 1 citedOpen Access
Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia
Seminars in Hematology·2000· 148 cited
Hemizygous Deletions of Chromosome Band 16q24 in Wilms Tumor
Cancer Genetics and Cytogenetics·1999· 21 cited
Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse
1999· 16 cited
SLUG, a ces-1-Related Zinc Finger Transcription Factor Gene with Antiapoptotic Activity, Is a Downstream Target of the E2A-HLF Oncoprotein
Molecular Cell·1999· 207 citedOpen Access
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Frequent Co-authors

Marcus B. Valentine(8), Toshiya Inaba(5), Adolfo A. Ferrando(4), Virginia Valentine(4), Frederick G. Behm(3), Takeshi Inukai(3), Susana C. Raimondi(3), Ching‐Hon Pui(3), Garrett M. Brodeur(3), Susan L. Cohn(3), Jack Sublett(3), Jennifer O’Neil(3), Midori Saito(3), David Malkin(2), Kent W. Jolly(2), Martin U. Kuefer(2), Stephan W. Morris(2), Tetsuharu Shinjyo(2), John M. Maris(2), R P Castleberry(2)