Maureen E. Balestra

Gladstone Institutes — United States

Medicine · Health Sciences

15h-index2.3kcitations18works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Alzheimer's disease research and treatments(8), Mitochondrial Function and Pathology(3), Lipoproteins and Cardiovascular Health(3), CRISPR and Genetic Engineering(3), Diabetes, Cardiovascular Risks, and Lipoproteins(2)

Publications18 total

Author Correction: Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease
Nature Aging·2021· 1 citedOpen Access
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease
Nature Aging·2021· 103 citedOpen Access
Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia
Acta Neuropathologica·2018· 38 cited
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Nature Medicine·2018· 426 citedOpen Access
Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells
Stem Cell Reports·2013· 126 citedOpen Access
Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor
Cell stem cell·2012· 530 citedOpen Access
Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
Journal of Biological Chemistry·2011· 154 citedOpen Access
Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors
Journal of Biological Chemistry·2011· 102 citedOpen Access
O3‐03–03: Apolipoprotein E4 and its fragment impair mitochondrial dynamics in neuronal cultures
Alzheimer s & Dementia·2008· 4 cited
Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS
Journal of Neuroscience·2008· 124 citedOpen Access
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons
Proceedings of the National Academy of Sciences·2008· 85 citedOpen Access
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
Proceedings of the National Academy of Sciences·2005· 308 citedOpen Access
Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting
Biochemical Journal·2003· 18 citedOpen Access
Human apolipoprotein E7: lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins
Journal of Lipid Research·2000· 11 citedOpen Access
Effect of Arginine 172 on the Binding of Apolipoprotein E to the Low Density Lipoprotein Receptor
Journal of Biological Chemistry·2000· 66 citedOpen Access
Low Expression of the Apolipoprotein B mRNA–Editing Transgene in Mice Reduces LDL Levels but Does Not Cause Liver Dysplasia or Tumors
Arteriosclerosis Thrombosis and Vascular Biology·1998· 42 citedOpen Access
Two Distinct TATA-less Promoters Direct Tissue-specific Expression of the Rat Apo-B Editing Catalytic Polypeptide 1 Gene
Journal of Biological Chemistry·1997· 18 citedOpen Access
Differences in Receptor Binding of LDL Subfractions
Arteriosclerosis Thrombosis and Vascular Biology·1996· 110 cited

Frequent Co-authors

Yadong Huang(12), David Walker(5), Robert W. Mahley(5), Jens Brodbeck(5), Karl H. Weisgraber(5), Thomas L. Innerarity(5), Qin Xu(3), Seo Yeon Yoon(3), Bruce L. Miller(3), Stephen B. Freedman(3), K S Arnold(3), Xiaobing Qian(3), Karen Ring(2), Leslie M. Tong(2), Gang Li(2), Chengzhong Wang(2), Dah-Eun Jeong(2), R. Dennis Miranda(2), Zhaoping Liu(2), Anke Meyer‐Franke(2)