Tom D. McCarthy

Chemistry · Physical Sciences

21h-index1.9kcitations50works0.02yr avg
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Research Topics

Asymmetric Synthesis and Catalysis(12), Crystallization and Solubility Studies(6), X-ray Diffraction in Crystallography(6), Chemical Synthesis and Analysis(5), Advanced Synthetic Organic Chemistry(5)

Publications50 total

Abstract 1631: GPR65 is a critical mediator of low pH induced immunosuppressive signalling in tumor associated macrophages: Human target validation of GPR65 as a novel innate immune checkpoint and discovery of potent, selective GPR65 antagonists
Cancer Research·2021· 4 cited
Angiotensin 2 type 2 receptor blockade is a novel target for murine osteoarthritis pain
Osteoarthritis and Cartilage·2019
Vanity's Residue
NOVEL A Forum on Fiction·2018· 2 cited
Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons
Molecular Pain·2016· 27 citedOpen Access
Chapter 8. The Cognitively Impaired Patient
American Psychiatric Association Publishing eBooks·2015
Mechanisms Underlying Clinical Efficacy of Angiotensin II Type 2 Receptor (AT<sub>2</sub>R) Antagonist EMA401 in Neuropathic Pain: Clinical Tissue and in Vitro Studies
Molecular Pain·2015· 56 citedOpen Access
Development of EMA401 as an orally‐administered, highly‐selective angiotensin II type 2 receptor antagonist for the treatment of neuropathic pain
Journal of the Peripheral Nervous System·2014· 4 cited
EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial
The Lancet·2014· 194 cited
Angiotensin<scp>II</scp>type 2 receptor (<scp>AT<sub>2</sub>R</scp>) localization and antagonist‐mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons
European Journal of Pain·2012· 96 citedOpen Access
Structure Activity Relationship of Dendrimer Microbicides with Dual Action Antiviral Activity
PLoS ONE·2010· 171 citedOpen Access
Inhibition of destructive autoimmune arthritis in FcγRIIa transgenic mice by small chemical entities
Immunology and Cell Biology·2008· 41 cited
Preclinical Safety and Efficacy Assessments of Dendrimer-Based (SPL7013) Microbicide Gel Formulations in a Nonhuman Primate Model
Antimicrobial Agents and Chemotherapy·2006· 111 citedOpen Access
Dendrimers As Drugs: Discovery, Preclinical and Clinical Development of SPL7013 Gel (VivaGel™), a Dendrimer Based Microbicide for HIVand STI Prevention
Retrovirology·2005· 1 citedOpen Access
Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses
Antiviral Research·2005· 86 cited
Dendrimers as Drugs:  Discovery and Preclinical and Clinical Development of Dendrimer-Based Microbicides for HIV and STI Prevention
Molecular Pharmaceutics·2005· 313 cited
SPL7013 Gel as a Topical Microbicide for Prevention of Vaginal Transmission of SHIV <sub>89.6P</sub> in Macaques
AIDS Research and Human Retroviruses·2005· 164 cited
CCDC 175704: Experimental Crystal Structure Determination
The Cambridge Structural Database·2004Open Access
CCDC 175705: Experimental Crystal Structure Determination
The Cambridge Structural Database·2004Open Access
Stereoselective Synthesis of β-Amino-α-Fluoro Esters via Diastereoselective Fluorination of Enantiopure β-Amino Enolates
Synlett·2004· 7 cited
Asymmetric synthesis and applications of β-amino Weinreb amides: asymmetric synthesis of (S)-coniine
Organic & Biomolecular Chemistry·2004· 65 cited
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Frequent Co-authors

R. F. C. BROWN(10), Peter J. Duggan(9), Andrew C. Donohue(7), Barry Matthews(6), Stephen G. Davies(6), W. Roy Jackson(6), W. R. JACKSON(5), Gary D. Fallon(5), Anna C. Peatt(5), P.C. Andrews(5), George Holan(4), Praveen Anand(4), C. Bountra(4), Darren J. Cundy(4), Philip C. Andrews(4), Karen M. Bromfield(4), A.M. Dodd(4), Sandhya A. M. Duggan(4), Peter Karellas(3), Scott Henderson(3)