Hiroyoshi Hidaka

Mie University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

62h-index16.6kcitations590works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(92), Phosphodiesterase function and regulation(52), Nitric Oxide and Endothelin Effects(44), Receptor Mechanisms and Signaling(26), Ion channel regulation and function(25)

Publications590 total

Phase Ⅰ/Ⅱ, Double-Masked, Randomized, Vehicle-Controlled Study of H-1337 Ophthalmic Solution for Glaucoma and Ocular Hypertension
Ophthalmology Glaucoma·2022· 4 cited
The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats
Cells·2021· 5 citedOpen Access
Isoquinoline sulfonamides such as fasudil, H-1152, ripasudil and H-1129 produce IOP-lowering and neuroprotective effects through Rho kinase inhibition
Investigative Ophthalmology & Visual Science·2018· 2 citedOpen Access
H-1129 suppresses neovascularization through inhibition of secretion of VEGF and proliferation of vascular endothelial cells
Investigative Ophthalmology & Visual Science·2017Open Access
Therapeutic potential of topical administration of H-1129, an isoquinoline sulfonamide derivative, in wet AMD and proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science·2017Open Access
Elucidation of molecular mechanism of H-1337, an anti-glaucoma agent
Investigative Ophthalmology & Visual Science·2015· 2 cited
Therapeutic potential of a novel isoquinoline sulfonamide derivative with protein kinase inhibition function, H-1337, in wet AMD
Investigative Ophthalmology & Visual Science·2015
A novel isoquinoline sulfonamide protein kinase inhibitor (H-1337) produces long-lasting reduction of IOP
Investigative Ophthalmology & Visual Science·2015· 4 cited
IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys
Bioorganic & Medicinal Chemistry Letters·2013· 23 cited
K-134, a Phosphodiesterase 3 Inhibitor, Prevents Brain Damage by Inhibiting Thrombus Formation in a Rat Cerebral Infarction Model
PLoS ONE·2012· 7 citedOpen Access
5094 Hsp90-binding Compound, H-1129, Produces IOP Lowering And Fibronectin Reduction
SciVee·2012
Efficient synthesis of [11C]H-1152, a PET probe specific for Rho-kinases, highly potential targets in diagnostic medicine and drug development
Tetrahedron·2012· 15 cited
Future prospective of phosphodiesterase-3 inhibitors as antithorombotic drug
Japanese Journal of Thrombosis and Hemostasis·2011Open Access
Erratum
Digestion·2009
The Effect of the Rho-Associated Protein Kinase Inhibitor, HA-1077, in the Rabbit Ocular Hypertension Model Induced by Water Loading
Current Eye Research·2009· 29 cited
The Effect of the H-1152P, a Potent Rho-Associated Coiled Coil-Formed Protein Kinase Inhibitor, in Rabbit Normal and Ocular Hypertensive Eyes
Current Eye Research·2009· 36 cited
Rho kinase阻害剤K‐115の眼圧下降作用および神経保護作用
Journal of Japanese Ophthalmological Society·2008
Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method
Biochemical and Biophysical Research Communications·2006· 4 cited
Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery
Prostaglandins Leukotrienes and Essential Fatty Acids·2006· 22 cited
PKC phosphorylates MARCKS Ser159 not only directly but also through RhoA/ROCK
Biochemical and Biophysical Research Communications·2006· 23 cited
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Frequent Co-authors

Toshio Tanaka(9), Michiko Naka(6), Yasuharu Sasaki(5), Masatoshi Hagiwara(5), Masaki Inagaki(4), Sachiyo Kawamoto(4), Ryōji Kobayashi(3), Toyoshi Endo(3), Shigeo Ohno(2), Hiroshi Kawasaki(2), Hisayuki Yokokura(2), Tokuo Yamaki(2), Masakatsu Nishikawa(2), Masaaki Suzuki(2), Masahisa Asano(2), Yasuo Watanabe(2), TOMIO TAKEUCHI(2), HAMAO UMEZAWA(2), Toshiharu Nagatsu(2), Hiroshi Kuzuya(2)