William J. Shufesky

University of Pittsburgh — United States

Immunology and Microbiology · Life Sciences

29h-index5.5kcitations73works1.42yr avg
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Research Topics

Immunotherapy and Immune Responses(36), T-cell and B-cell Immunology(22), Immune Cell Function and Interaction(20), Extracellular vesicles in disease(19), Neuropeptides and Animal Physiology(8)

Publications73 total

Exosome-primed T cell immunity is facilitated by complement activation
American Journal of Transplantation·2025· 2 citedOpen Access
Exosome-Mediated Allorecognition is Complement Dependent
American Journal of Transplantation·2025Open Access
Transplants foster B cell alloimmunity by relaying extracellular vesicles to follicular dendritic cells
Cell Reports·2025· 5 citedOpen Access
Fetoplacental extracellular vesicles deliver conceptus-derived antigens to maternal secondary lymphoid tissues for immune recognition
JCI Insight·2025Open Access
092 During skin hapten-sensitization Substance P promotes proinflammatory keratinocytes that secrete exosomes containing IL-1β resulting in efficient allergic contact dermatitis
Journal of Investigative Dermatology·2024Open Access
<i>Extracellular vesicles deliver feto-placental paternal antigens to maternal secondary lymphoid tissues for T cell recognition</i>
The Journal of Immunology·2023· 1 citedOpen Access
Skin codelivery of contact sensitizers and neurokinin-1 receptor antagonists integrated in microneedle arrays suppresses allergic contact dermatitis
Journal of Allergy and Clinical Immunology·2022· 14 citedOpen Access
Skin delivery of hapten and neurokinin-1 receptor antagonists by microneedle arrays targets neurogenic inflammation and prevents contact dermatitis
The Journal of Immunology·2021
Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation
Science Translational Medicine·2021· 45 citedOpen Access
060 Delivery of contact sensitizers and neurokinin 1 receptor antagonists by microneedle arrays targets different skin cells to abrogate contact dermatitis
Journal of Investigative Dermatology·2020
Blockade of the neurokinin-1 receptor in keratinocytes prevents neuroinflammation and decreases innate and adaptive immune responses in the skin
The Journal of Immunology·2020
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
Cell Reports·2020· 38 citedOpen Access
Oral administration of lipoteichoic acid from <i>Lactobacillus rhamnosus</i> GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice
European Journal of Immunology·2019· 38 citedOpen Access
Author response for "Oral administration of Lipoteichoic acid from &lt;i&gt;Lactobacillus rhamnosus&lt;/i&gt; GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice"
2019
Restraining neuroinflammation during antigen delivery as an immunosuppressive approach to prevent and treat contact dermatitis
The Journal of Immunology·2019
Author response for "Oral administration of Lipoteichoic acid from &lt;i&gt;Lactobacillus rhamnosus&lt;/i&gt; GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice"
2019
Neurokinin 1 receptor-signaling sustains T-cell survival during thymus development and following T-cell activation in secondary lymphoid organs
The Journal of Immunology·2018
055 Development of contact dermatitis in mice requires T cell signaling via the neurokinin 1 receptor at the site of dendritic cell T cell synapse
Journal of Investigative Dermatology·2018
Cross-dressing of recipient Ag-presenting cells with donor exosomes trigger direct T-cell allosensitization in transplantation
The Journal of Immunology·2017· 1 cited
The neurokinin 1 receptor and its agonists recruited at the DC-T cell synapse are necessary to promote the survival of activated T cells in vivo
The Journal of Immunology·2017· 1 cited
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Frequent Co-authors

Adrián E. Morelli(50), Adriana T. Larregina(32), О. Н. Ткачева(18), Angus W. Thomson(12), Simon C. Watkins(11), Tina L. Sumpter(11), Géza Erdös(10), Sherrie J. Divito(10), Louis D. Falo(10), Darling Rojas-Canales(8), Angela Montecalvo(7), Donna B. Stolz(7), Alicia R. Mathers(7), Mara Sullivan(6), Alan F. Zahorchak(6), Brian Janelsins(6), Paul D. Robbins(5), Mohna Bandyopadhyay(5), Zhiliang Wang(4), Glenn D. Papworth(4)