Louis A. Tartaglia

Proteostasis Therapeutics (United States) — United States

Neuroscience · Life Sciences

46h-index32.3kcitations57works0.02yr avg
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Research Topics

Regulation of Appetite and Obesity(19), Adipose Tissue and Metabolism(14), Biochemical Analysis and Sensing Techniques(13), Adipokines, Inflammation, and Metabolic Diseases(10), Redox biology and oxidative stress(9)

Publications57 total

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain
2026Open Access
Complementary new approaches enable repositioning of failed drug candidates
Expert Opinion on Investigational Drugs·2006· 44 cited
Mice Deleted for Fatty Acid Transport Protein 5 Have Defective Bile Acid Conjugation and Are Protected From Obesity
Gastroenterology·2006· 130 cited
Dual Specificity MAPK Phosphatase 3 Activates PEPCK Gene Transcription and Increases Gluconeogenesis in Rat Hepatoma Cells
Journal of Biological Chemistry·2005· 48 citedOpen Access
Enzymatic Characterization of the Pancreatic Islet-specific Glucose-6-Phosphatase-related Protein (IGRP)
Journal of Biological Chemistry·2004· 54 citedOpen Access
A thin commentary on a fat receptor
Cell·2004· 2 citedOpen Access
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation·2003· 5.8k citedOpen Access
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation·2003· 5.6k cited
Dual Specificity Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Plays a Potential Role in Insulin Resistance
Journal of Biological Chemistry·2003· 60 citedOpen Access
PTP1B Regulates Leptin Signal Transduction In Vivo
Developmental Cell·2002· 813 citedOpen Access
Erratum
Trends in Endocrinology and Metabolism·2001
A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.
PubMed·2001· 83 cited
Identification of leptin-induced transcripts in the mouse hypothalamus.
Diabetes·2000· 11 citedOpen Access
Medicinal strategies in the treatment of obesity
Nature·2000· 436 cited
Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor.
Diabetes·1999· 46 cited
Identification of the Major Intestinal Fatty Acid Transport Protein
Molecular Cell·1999· 409 citedOpen Access
Transport Function and Regulation of Mitochondrial Uncoupling Proteins 2 and 3
Journal of Biological Chemistry·1999· 325 citedOpen Access
Tyrosine Phosphorylation of Tub and Its Association with Src Homology 2 Domain-containing Proteins Implicate Tub in Intracellular Signaling by Insulin
Journal of Biological Chemistry·1999· 94 citedOpen Access
Existence of uncoupling protein‐2 antigen in isolated mitochondria from various tissues
FEBS Letters·1999· 15 citedOpen Access
Evidence for ligand‐independent homo‐oligomerization of leptin receptor (OB‐R) isoforms: A proposed mechanism permitting productive long‐form signaling in the presence of excess short‐form expression
Journal of Cellular Biochemistry·1999· 7 cited
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Frequent Co-authors

David V. Goeddel(10), Gisela Storz(9), David W. White(7), Marlene Dembski(6), Ruth E. Gimeno(6), René Devos(4), Rudolph L. Leibel(4), Bruce N. Ames(4), Haiyan Xu(3), Qing Yang(3), Daseng Yang(3), Chieh Jason Chou(3), Xun Weng(3), A Moriarty(3), Jay P. Morgenstern(3), G H Wong(3), Streamson C. Chua(3), Heinz Baumann(3), Karen K. Kuropatwinski(3), B N Ames(3)