Mikiyasu Shirai

National Cerebral and Cardiovascular Center — Japan

Medicine · Health Sciences

32h-index3.5kcitations164works1.52yr avg
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Research Topics

Pulmonary Hypertension Research and Treatments(31), Heart Rate Variability and Autonomic Control(28), Nitric Oxide and Endothelin Effects(24), Cardiovascular Function and Risk Factors(24), Regulation of Appetite and Obesity(16)

Publications164 total

The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension
Journal of Molecular and Cellular Cardiology Plus·2024· 3 citedOpen Access
Rho-Kinase Inhibition Attenuates Elevated Myofilament Ca2+ Sensitivity and Improves Sarcomere Function in Salt-Sensitive Prediabetic Rats
SSRN Electronic Journal·2024Open Access
Abstract 9592: The Super Relaxed State of Myosin Contributes to the Pathogenesis of Right Ventricular Dysfunction in Pulmonary Hypertension
Circulation·2022
Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models
Frontiers in Physiology·2022· 2 citedOpen Access
EFFECTS OF A GLUCAGON LIKE PEPTIDE-1 AGONIST AND RHO-KINASE INHIBITOR ON PULMONARY AND RIGHT VENTRICLE FUNCTION IN PULMONARY HYPERTENSIVE RATS WITH AND WITHOUT INSULIN RESISTANCE
Journal of Hypertension·2021
Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography
American Journal of Physiology-Heart and Circulatory Physiology·2021· 5 cited
β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat
Clinical Science·2021· 13 cited
Exercise Regulates MicroRNAs to Preserve Coronary and Cardiac Function in the Diabetic Heart
Circulation Research·2020· 84 citedOpen Access
Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction
Cardiovascular Research·2020· 16 cited
Biomedical Micro-CT and Micro-angiography Systems Using High Megapixel Digital Single-lens Reflex Cameras and Synchrotron Radiation
2020· 1 cited
Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet
Cardiovascular Diabetology·2020· 49 citedOpen Access
Inflammatory Cytokines in the Pathogenesis of Pulmonary Arterial Hypertension
2020· 2 citedOpen Access
Impaired Right Coronary Vasodilator Function in Pulmonary Hypertensive Rats Assessed by In Vivo Synchrotron Microangiography
2020Open Access
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model
Journal of Molecular and Cellular Cardiology·2019· 39 citedOpen Access
Investigating In Vivo Myocardial and Coronary Molecular Pathophysiology in Mice with X-Ray Radiation Imaging Approaches
2019Open Access
Ghrelin and vascular protection
Vascular Biology·2019· 12 citedOpen Access
Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction
The Journal of Biochemistry·2019· 14 citedOpen Access
Renal and Lumbar Sympathetic Nerve Activity During Development of Hypertension in Dahl Salt-Sensitive Rats
Hypertension·2019· 19 citedOpen Access
Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet
Journal of Pharmacology and Experimental Therapeutics·2019· 21 cited
Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice
Journal of Cachexia Sarcopenia and Muscle·2018· 46 citedOpen Access
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Frequent Co-authors

James T. Pearson(27), Hirotsugu Tsuchimochi(21), Daryl O. Schwenke(20), Takashi Sonobe(17), Kenji Kangawa(16), Keiji Umetani(16), Yutaka Fujii(10), Tadakatsu Inagaki(8), Naoto Yagi(6), Akito Shimouchi(6), Amanda J. Edgley(6), Misa Yoshimoto(6), Hidezo Mori(5), Darren J. Kelly(5), Tsuyoshi Akiyama(5), Hiroshi Hosoda(4), Noritoshi Nagaya(4), Takeshi Tokudome(4), Yi Ching Chen(4), Mark T. Waddingham(4)