Yoshihide Nakano

Takeda (Japan) — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index361citations18works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(6), Regulation of Appetite and Obesity(5), Biochemical Analysis and Sensing Techniques(5), Stress Responses and Cortisol(3), Pancreatic function and diabetes(3)

Publications18 total

Identification and Characterization of a New Series of Ghrelin O-Acyl Transferase Inhibitors
SLAS DISCOVERY·2017· 17 citedOpen Access
Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition
Bioorganic & Medicinal Chemistry·2017· 12 citedOpen Access
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus
Bioorganic & Medicinal Chemistry·2017· 27 citedOpen Access
新規ソマトスタチン受容体サブタイプ5(SSTR5)きっ抗薬の発見:薬物動態学的プロファイルとヒトEther‐a‐go‐go‐関連遺伝子(hERG)阻害を改善するための薬理学的研究と設計【Powered by NICT】
Bioorganic & Medicinal Chemistry·2017
タイプ2糖尿病の治療のための強力で選択的かつ経口的に利用できるソマトスタチン受容体サブタイプ5(SSTR5)アンタゴニストとしての新規5-オキサ-2,6-ジアザスピロ[3.4]oct-6-エン誘導体の発見【Powered by NICT】
Bioorganic & Medicinal Chemistry·2017
CCDC 859003: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Investigation of Fat Metabolism during Antiobesity Interventions by Magnetic Resonance Imaging and Spectroscopy
Magnetic Resonance Insights·2014· 3 citedOpen Access
Corrigendum to “Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors” [Bioorg. Med. Chem. Lett. 22 (2012) 4769–4772]
Bioorganic & Medicinal Chemistry Letters·2012· 3 cited
Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 41 citedOpen Access
Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities
Journal of Medicinal Chemistry·2012· 19 citedOpen Access
Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines
Journal of Medicinal Chemistry·2012· 31 citedOpen Access
Melanin-concentrating hormone receptor 1 antagonists: Synthesis, structure–activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
Bioorganic & Medicinal Chemistry·2011· 14 citedOpen Access
Discovery, synthesis, and structure–activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists
Bioorganic & Medicinal Chemistry·2011· 10 citedOpen Access
Characterization of a novel ghrelin cell reporter mouse
Regulatory Peptides·2009· 96 citedOpen Access
Novel Benzodioxan Derivative, 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole HC1 (MKC-242), with a Highly Potent and Selective Agonist Activity at Rat Central Serotonin1A Receptors
The Japanese Journal of Pharmacology·1995· 53 citedOpen Access
Mechanisms of acetylcholine release by thyrotropin-releasing hormone in the hippocampus of free-moving rats
The Japanese Journal of Pharmacology·1995Open Access
Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice
European Journal of Pharmacology·1992· 14 cited
Gonadectomy changes the pituitaiy-adrenocortical response in mice to S-HT1A receptor agonists
European Journal of Pharmacology·1991· 21 cited

Frequent Co-authors

Shizuo Kasai(8), Makoto Kamata(7), Shiro Takekawa(6), Nobuhiro Suzuki(5), Hitomi Ogino(5), Yasutaka Nagisa(5), Yuji Ishihara(5), Asato Kina(4), Michiko Tawada(4), Masahiro Kamaura(4), Tomoko Kaisho(4), Koki Kato(4), Hideki Hirose(4), Takeshi Yamasaki(4), Jun Sugama(4), Shinji Iwasaki(4), Tsuyoshi Maekawa(4), Kaoru Watanabe(4), Toshio Matsuda(3), Takashi Yamashita(3)