Charles R. Kissinger

Medicine · Health Sciences

29h-index7.3kcitations48works0.02yr avg
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Research Topics

Hepatitis C virus research(14), Protein Structure and Dynamics(9), HIV/AIDS drug development and treatment(9), Signaling Pathways in Disease(9), Enzyme Structure and Function(8)

Publications48 total

J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats
Frontiers in Neurology·2022· 8 citedOpen Access
Building a Three-Dimensional Model of CYP2C9 Inhibition Using the Autocorrelator: An Autonomous Model Generator
Journal of Chemical Information and Modeling·2012· 7 cited
Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2009· 43 cited
5,5′- and 6,6′-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2009· 14 cited
Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor
2009
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents
Bioorganic & Medicinal Chemistry Letters·2008· 23 cited
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2008· 17 citedOpen Access
4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2008· 26 citedOpen Access
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2008· 30 citedOpen Access
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
Bioorganic & Medicinal Chemistry Letters·2008· 37 citedOpen Access
Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 61 cited
Structure of hepatitis C virus IRES subdomain IIa
Acta Crystallographica Section D Biological Crystallography·2008· 30 cited
Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with small molecule fragments
2008
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments
Bioorganic & Medicinal Chemistry Letters·2008· 35 cited
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents
Bioorganic & Medicinal Chemistry Letters·2008· 30 cited
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine
Bioorganic & Medicinal Chemistry Letters·2008· 41 citedOpen Access
<i>Deposit3D</i>: a tool for automating structure depositions to the Protein Data Bank
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2005· 2 citedOpen Access
Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins Structure Function and Bioinformatics·2005· 245 cited
Crystal Structure of Human ABAD/HSD10 with a Bound Inhibitor: Implications for Design of Alzheimer's Disease Therapeutics
Journal of Molecular Biology·2004· 97 cited
Identifying disordered regions in proteins from amino acid sequence
Proceedings of International Conference on Neural Networks (ICNN'97)·2002· 239 cited
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Frequent Co-authors

Richard E. Showalter(18), J. Ernest Villafranca(14), Laurie A. LeBrun(11), Frank Ruebsam(10), Yuefen Zhou(10), Stephen E. Webber(10), Amit Shah(10), Mei Tsan(10), Rupal Patel(10), Maria V. Sergeeva(10), Chinh Van Tran(9), Qing Han(9), Leo Kirkovsky(9), Laura A. Pelletier(8), Peter S. Dragovich(8), Douglas E. Murphy(8), Lian‐Sheng Li(8), Ruhi Kamran(7), Darian M. Bartkowski(7), Thomas G. Nolan(7)