Annick You-Ten

University Health Network — Canada

Medicine · Health Sciences

20h-index3.2kcitations25works5.02yr avg
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Research Topics

Cancer-related Molecular Pathways(4), Immune Cell Function and Interaction(4), Ubiquitin and proteasome pathways(4), DNA Repair Mechanisms(3), Epigenetics and DNA Methylation(3)

Publications25 total

B cell–derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor–mediated signaling
Proceedings of the National Academy of Sciences·2025· 5 citedOpen Access
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
The Journal of Immunology·2023· 2 citedOpen Access
Abstract A16: Multi-omic analyses in genetically engineered mice reveal distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
Blood Cancer Discovery·2023
Distinct and opposite effects of leukemogenic <i>Idh</i> and <i>Tet2</i> mutations in hematopoietic stem and progenitor cells
Proceedings of the National Academy of Sciences·2023· 20 citedOpen Access
The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
Immunity·2022· 119 citedOpen Access
The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer
Cell Death and Differentiation·2021· 30 citedOpen Access
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
Cancer Cell·2020· 91 citedOpen Access
DIPG-13. A NOVEL MOUSE MODEL REVEALS UNEXPECTED MECHANISMS OF ACTION OF ACVR1 MUTATIONS IN DIFFUSE INTRINSIC PONTINE GLIOMA
Neuro-Oncology·2019Open Access
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
Nature Communications·2017· 52 citedOpen Access
Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio
Cell Death and Differentiation·2015· 102 citedOpen Access
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis
Proceedings of the National Academy of Sciences·2015· 26 citedOpen Access
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
Genes & Development·2013· 135 citedOpen Access
Involvement of Toso in activation of monocytes, macrophages, and granulocytes
Proceedings of the National Academy of Sciences·2013· 78 citedOpen Access
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system
Nature Immunology·2012· 39 cited
Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model
Oncogene·2012· 54 citedOpen Access
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Nature·2012· 506 citedOpen Access
The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis
The Journal of Experimental Medicine·2012· 64 citedOpen Access
Generation and Characterization of the Anp32e-Deficient Mouse
PLoS ONE·2010· 28 citedOpen Access
Identification of <i>BERP</i> (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA <sub>A</sub> receptors
Proceedings of the National Academy of Sciences·2010· 34 citedOpen Access
Determinating the role of the E3 Ubiquitin Ligase Ariadne 2 in mammalian systemss
Clinical and investigative medicine·2007
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Frequent Co-authors

Andrew Wakeham(22), Tak W. Mak(21), Jillian Haight(15), Pamela S. Ohashi(8), Andrew Elia(8), Bryan E. Snow(8), Wanda Y. Li(7), Thorsten Berger(7), Gordon S. Duncan(6), Dirk Brenner(5), Zhenyue Hao(5), Jérôme Fortin(5), Satoshi Inoue(4), Jennifer Silvester(4), Parameswaran Ramachandran(4), Chantal Tobin(4), Masato Sasaki(3), Isaac S. Harris(3), Ari Melnick(3), Carol C. Cheung(3)