Paul R. Ortiz de Montellano

University of California, San Francisco — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

76h-index21.5kcitations365works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(116), Hemoglobin structure and function(84), Heme Oxygenase-1 and Carbon Monoxide(68), Metal-Catalyzed Oxygenation Mechanisms(54), Nitric Oxide and Endothelin Effects(28)

Publications365 total

The Cytochrome P450 Oxidative System
2019· 15 cited
Acetylenes: cytochrome P450 oxidation and mechanism-based enzyme inactivation
Drug Metabolism Reviews·2019· 18 citedOpen Access
Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity
Drug Metabolism and Disposition·2018· 3 citedOpen Access
Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system
Journal of Inorganic Biochemistry·2018· 41 citedOpen Access
1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
Medicinal Chemistry·2018· 75 citedOpen Access
A New Step in the Treatment of Sickle Cell Disease
Biochemistry·2017· 19 cited
Crystal structures of the CO and NO Bound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis
Archives of Biochemistry and Biophysics·2016· 15 citedOpen Access
Distal Hydrogen-bonding Interactions in Ligand Sensing and Signaling by Mycobacterium tuberculosis DosS
Journal of Biological Chemistry·2016· 19 citedOpen Access
Cholesterol Analogs with Degradation-resistant Alkyl Side Chains Are Effective Mycobacterium tuberculosis Growth Inhibitors
Journal of Biological Chemistry·2016· 22 citedOpen Access
Self-catalyzed destruction of cytocl ethynyl sterols to prosthetic heme (biooxidation/porphyrins/green pigment/acetylene metabolism)
2016
N-Methylprotoporphyrin IX: Chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4- dihydrocollidine treatment (N-alkyl porphyrins/porphyrin synthesis/ferrochelatase inhibitor/NMR)
2016
Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from <i>Mycobacterium smegmatis</i>
Biochemistry·2015· 22 citedOpen Access
Self-processing of Peroxidases
2015· 3 cited
Heme and I
Journal of Biological Chemistry·2015· 2 citedOpen Access
Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography
Journal of Biological Chemistry·2015· 30 citedOpen Access
Substrate Oxidation by Cytochrome P450 Enzymes
2015· 93 cited
Cytochrome P450
2015· 249 cited
Cholesterol Ester Oxidation by Mycobacterial Cytochrome P450
Journal of Biological Chemistry·2014· 35 citedOpen Access
Carbon-Carbon Bond Cleavage in Activation of the Prodrug Nabumetone
Drug Metabolism and Disposition·2014· 41 cited
Role of Cytochrome P450 Enzymes in Biotransformation
Handbook of Metabolic Pathways of Xenobiotics·2014· 1 cited
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Frequent Co-authors

Angela Wilks(6), James J. De Voss(4), T.L. Poulos(3), David J. Schuller(3), Pierre Moënne‐Loccoz(3), Thomas M. Loehr(3), Ignacio Rodríguez‐Crespo(2), Nancy Counts Gerber(2), Akram Alian(2), Hugues Ouellet(2), Jonathan B. Johnston(2), Huiying Li(2), Karine Auclair(2), Yi Liu(2), Richard A. Tschirret-Guth(2), Ronald P. Mason(2), Alma L. Burlingame(2), Clinton R. Nishida(2), Zhi-Ping Chen(1), Ken I. Mitchelhill(1)