R. Micheletti

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.9kcitations67works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(23), Neuropeptides and Animal Physiology(14), Ion channel regulation and function(11), Mitochondrial Function and Pathology(8), Ion Transport and Channel Regulation(7)

Publications67 total

Multi Omic Profiling Identifies PUFINs: Novel Long Non Coding RNAs (lncRNAs) Regulating Pulmonary Myofibroblast Activation in Fibrosis
2024
"Role of long non-coing RNAs in the stressed heart". Wisper : a novel cardiac fibroblast-enriched IncRNA that modulate fibrosis in the failing heart
IRIS·2016
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs
European Heart Journal·2014· 283 citedOpen Access
Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone
Journal of Hypertension·2010· 2 cited
Novel analogues of Istaroxime, a potent inhibitor of Na+,K+-ATPase: Synthesis, structure–activity relationship and 3D-quantitative structure–activity relationship of derivatives at position 6 on the androstane scaffold
Bioorganic & Medicinal Chemistry·2010· 16 cited
Novel Analogues of Istaroxime, a Potent Inhibitor of Na<sup>+</sup>,K<sup>+</sup>-ATPase: Synthesis and Structure−Activity Relationship
Journal of Medicinal Chemistry·2008· 23 cited
Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model
Journal of Pharmacology and Experimental Therapeutics·2008· 39 cited
Matrix Metalloprotease Activity Is Enhanced in the Compensated but Not in the Decompensated Phase of Pressure Overload Hypertrophy
American Journal of Hypertension·2007· 26 cited
Targeting SERCA2a as an innovative approach to the therapy of congestive heart failure
Medical Hypotheses·2006· 6 cited
Istaroxime, a Stimulator of Sarcoplasmic Reticulum Calcium Adenosine Triphosphatase Isoform 2a Activity, as a Novel Therapeutic Approach to Heart Failure
The American Journal of Cardiology·2006· 63 cited
Modulation of Sarcoplasmic Reticulum Function by Na+/K+ Pump Inhibitors with Different Toxicity: Digoxin and PST2744 [(E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride]
Journal of Pharmacology and Experimental Therapeutics·2005· 61 cited
CARDIOVASCULAR EFFECTS OF CHRONIC LOW-DOSE OUABAIN ADMINISTRATION IN RATS
Journal of Hypertension·2004
Structure-Based Design and Synthesis of Novel Potent Na<sup>+</sup>,K<sup>+</sup>-ATPase Inhibitors Derived from a 5α,14α-Androstane Scaffold as Positive Inotropic Compounds
Journal of Medicinal Chemistry·2003· 39 citedOpen Access
328 Inhibition of the “transient inward current” by PST2744, a Na+/K+ pump blocker with low toxicity
European Journal of Heart Failure Supplements·2003
327 Modulation of intracellular Ca2+ dynamics by PST2744, a Na+/K+ pump blocker with low toxicity
European Journal of Heart Failure Supplements·2003
Diverse Toxicity Associated with Cardiac Na+/K+ Pump Inhibition: Evaluation of Electrophysiological Mechanisms
Journal of Pharmacology and Experimental Therapeutics·2003· 56 cited
Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)
Journal of Pharmacology and Experimental Therapeutics·2002· 64 cited
17β-<i>O</i>-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity:  Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na<sup>+</sup>,K<sup>+</sup>-ATPase Receptor
Journal of Medicinal Chemistry·2000· 30 citedOpen Access
Effect of Propionyl-L-Carnitine on the Mechanics of Right and Left Papillary Muscles from Volume-Overloaded Rat Hearts
Journal of Cardiovascular Pharmacology·1996· 8 cited
Effect of propionyl-l-carnitine and enalapril on cardiac function of pressure-overloaded rats during increase in load
European Journal of Pharmacology·1995· 1 cited
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Frequent Co-authors

Giuseppe Bianchi(12), Paolo Ferrari(12), Antonio Giachetti(11), Achille Schiavone(11), Antonio Schiavone(9), A. Donetti(8), Giuseppe Giacalone(7), E. Montagna(6), E. Giraldo(5), A. Sagrada(5), Enzo Cereda(5), Marcella Rocchetti(4), Antonio Zaza(4), Marco Turconi(4), Piero Melloni(3), Paolo Barassi(3), Barbara Moro(3), Massimo Di Nicola(3), Gaspare Mostacciuolo(3), Alberto Cerri(3)