Cheng-Ming Chiang

The University of Texas Southwestern Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index7.3kcitations71works0.72yr avg
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Research Topics

Protein Degradation and Inhibitors(23), Ubiquitin and proteasome pathways(22), Genomics and Chromatin Dynamics(20), RNA modifications and cancer(15), Epigenetics and DNA Methylation(11)

Publications68 total

Mechanistic insights and <i>in vivo</i> HIV suppression by the BRD4-targeting small molecule ZL0580
2025Open Access
BRD4 binds the nucleosome via both histone and DNA interactions
2025· 2 citedOpen Access
ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss
Molecular Cell·2024Open Access
Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome
Science Advances·2021· 14 citedOpen Access
Expression of Phosphorylated BRD4 Is Markedly Associated with the Activation Status of the PP2A Pathway and Shows a Strong Prognostic Value in Triple Negative Breast Cancer Patients
Cancers·2021· 12 citedOpen Access
Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development
Journal of Medicinal Chemistry·2021· 126 citedOpen Access
BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination
JCI Insight·2020· 27 citedOpen Access
Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer
Scientific Reports·2020· 15 citedOpen Access
Opposing Functions of BRD4 Isoforms in Breast Cancer
Molecular Cell·2020· 198 citedOpen Access
KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs
Molecular Cell·2020· 62 citedOpen Access
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
Nucleic Acids Research·2020· 229 citedOpen Access
EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer
Nature Cancer·2020· 89 citedOpen Access
<i>N6</i>-methyladenosine-induced ERRγ triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming
Theranostics·2020· 66 citedOpen Access
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
Genes & Development·2019· 136 citedOpen Access
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
Nature Communications·2019· 30 citedOpen Access
Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus
Nature Communications·2019· 337 citedOpen Access
Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
Cell Death and Differentiation·2019· 106 citedOpen Access
TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial–mesenchymal transition and metastasis in liver cancer
Oncogene·2018· 54 citedOpen Access
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
Nucleic Acids Research·2018· 121 citedOpen Access
SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation
Cell Research·2018· 38 citedOpen Access
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Frequent Co-authors

Shwu-Yuan Wu(24), Mary C. Thomas(4), Jongsook Kim Kemper(3), Robert G. Roeder(3), Zhuojia Chen(3), Hongsheng Wang(3), James E. Bradner(2), Bhaskar Ponugoti(2), Dong-Hyun Kim(2), Zhen Xiao(2), Yanxi Peng(2), Hsien-Tsung Lai(2), Kai Ge(2), Sankari Nagarajan(2), Malik Alawi(2), Zeynab Najafova(2), Daniela Indenbirken(2), Upasana Bedi(2), Stefan Knapp(2), Adam Grundhoff(2)