H. K. Hariprakasha

Chemistry · Physical Sciences

9h-index232citations32works0.02yr avg
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Research Topics

Synthetic Organic Chemistry Methods(9), Cancer Treatment and Pharmacology(7), Supramolecular Chemistry and Complexes(4), Cancer therapeutics and mechanisms(4), Crystallization and Solubility Studies(4)

Publications32 total

Club Cell Protein, CC10, Attenuates Acute Respiratory Distress Syndrome Induced by Smoke Inhalation
Shock·2019· 12 cited
ROS-Mediated Modification of RhCC10 Protein for Potential Gain of Function
Free Radical Biology and Medicine·2016
Abstract 1231: <i>In vitro</i> anticancer activity of imidazo-acridinone (HKH40A) in panels of human patient-derived tumor xenografts (PDXs) and human leukemia and lymphoma cell lines
Cancer Research·2014
Growth inhibition of hepatocellular carcinoma cells in vitro and in vivo by the 8-methoxy analog of WMC79
Cancer Chemotherapy and Pharmacology·2008· 16 cited
Optimization of Naphthalimide-imidazoacridone with Potent Antitumor Activity Leading to Clinical Candidate (HKH40A, RTA 502)
Journal of Medicinal Chemistry·2007· 25 cited
Gene expression profiles in HCT116 and HT29 cells exposed to RTA 502 lead to insights into the mechanism of action
Cancer Research·2007· 2 cited
288 POSTER Selective targeting of critical components of DNA replication by HKH40A (RTA 502)
European Journal of Cancer Supplements·2006
A New Synthetic Agent with Potent but Selective Cytotoxic Activity against Cancer
Journal of Medicinal Chemistry·2005· 42 cited
Synthesis of Trishomocubane Amino Acid Derivatives
South African Journal of Chemistry·2005· 3 citedOpen Access
549 HKH40A, potent agent agaist GI cancers, targets p53 or when that is mutated, Akt
European Journal of Cancer Supplements·2004
Complete NMR elucidation of a novel trishomocubane hydantoin and its mono‐ and bis‐<i>t</i>‐Boc protected derivatives
Magnetic Resonance in Chemistry·2004· 14 cited
Synthesis and transport studies of a new class of cage-annulated chiral macrocycles
Tetrahedron Asymmetry·2003· 34 cited
CCDC 153573: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
Synthesis of novel cage-annnulated fluoromacrocycles
ARKIVOC·2002Open Access
ChemInform Abstract: Synthesis, Alkali Metal Picrate Extraction, and Alkali Metal Cation Binding Selectivities of Some New Cage‐Annulated Polyoxamacrocyclic Crown Ethers.
ChemInform·2002
ChemInform Abstract: Synthesis of 2,5‐Dimethylpentacyclo‐ [5.4.0.0<sup>2,5</sup>.0<sup>3,9</sup>.0<sup>4.8</sup>]decane (III).
ChemInform·2001
Synthesis, alkali metal picrate extraction, and alkali metal cation binding selectivities of some new cage‐annulated polyoxamacrocyclic crown ethers
Journal of Heterocyclic Chemistry·2001· 25 cited
Stereoelectronic Control of Additions of Vinylmagnesium Bromide to 1-Methyland 3-Methylpentacyclo[5.4.0.02,6.03,10.05.9]undecane-8,11-diones and to 1-Methylhexacyclo[10.2.1.0.02,11.04,9.04,14.09,13]pentadeca-5,7-diene-3,10-dione
Structural Chemistry·2001
Synthesis of Novel Cage Oxaheterocycles
The Journal of Organic Chemistry·2001· 37 cited
CCDC 169357: Experimental Crystal Structure Determination
The Cambridge Structural Database·2001Open Access
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Frequent Co-authors

Alan P. Marchand(10), Christopher J. Michejda(7), Teresa Kosakowska‐Cholody(6), S.G. Bodige(6), Wieslaw M. Cholody(5), Irishi N. N. Namboothiri(4), G. S. R. Subba Rao(4), Jason M. Keith(4), Sulejman Alihodžić(4), A.W. Somers(4), Trevor D. Power(4), W.H. Watson(4), Thavendran Govender(3), Hendrik G. Kruger(3), Mohamed Takhi(3), A.P. Marchand(3), Bishwajit Ganguly(3), Zilin Huang(2), Zhibing Chen(2), Jennifer S. Brodbelt(2)