Shuming Yin

East China Normal University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index954citations25works5.32yr avg
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Research Topics

CRISPR and Genetic Engineering(17), Virus-based gene therapy research(9), RNA Interference and Gene Delivery(5), RNA regulation and disease(5), RNA and protein synthesis mechanisms(4)

Publications25 total

Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope
Nature Communications·2026Open Access
LNP‐mediated in vivo base editing corrects Agxt to cure primary hyperoxaluria type 1
Clinical and Translational Medicine·2025Open Access
Construction of pathogenic <i>Sec16a</i> mutation mouse model using <scp>CRISPR</scp>/Cas9
Animal Models and Experimental Medicine·2025· 1 citedOpen Access
Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo
Nature Biotechnology·2025· 8 cited
Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model
Molecular Therapy·2024· 7 citedOpen Access
Lipid nanoparticle-mediated base-editing of the Hao1 gene achieves sustainable primary hyperoxaluria type 1 therapy in rats
Science China Life Sciences·2024· 2 cited
Corrigendum to “Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration” [Journal of Genetics and Genomics (2022) 49, 1114–1126]
Journal of genetics and genomics/Journal of Genetics and Genomics·2024
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Nature Chemical Biology·2024· 24 cited
A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing
Cellular and Molecular Immunology·2023· 18 citedOpen Access
Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies
Molecular Therapy·2022· 35 citedOpen Access
Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration
Journal of genetics and genomics/Journal of Genetics and Genomics·2022· 20 cited
Amelioration of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration
2021· 3 citedOpen Access
Amelioration of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration
2021· 1 citedOpen Access
Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor
Science China Life Sciences·2020· 34 cited
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Nature Biotechnology·2020· 287 cited
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain
Nature Cell Biology·2020· 136 cited
Amelioration of an Inherited Metabolic Liver Disease through Creation of a De Novo Start Codon by Cytidine Base Editing
Molecular Therapy·2020· 35 citedOpen Access
Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies
Cell Research·2020· 71 citedOpen Access
Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants
Protein & Cell·2019· 65 citedOpen Access
Correction: Cas9-nickase–mediated genome editing corrects hereditary tyrosinemia in rats.
Journal of Biological Chemistry·2019· 2 citedOpen Access
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Frequent Co-authors

Dali Li(20), Mingyao Liu(16), Lei Yang(15), Liren Wang(15), Honghui Han(10), Hongquan Geng(9), Rui Zheng(9), Meizhen Liu(8), Xiaohui Zhang(6), Xueyun Ma(6), Yuting Guan(6), Yang Liu(5), Xi Chen(5), Yanan Huo(5), Jiazhi Hu(5), Xi Chen(5), Biyun Zhu(4), Weishi Yu(4), Wei Yu(4), Yanjiao Shao(4)