Zhuchi Tu

Jinan University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.7kcitations31works8.22yr avg
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Research Topics

CRISPR and Genetic Engineering(16), Genetic Neurodegenerative Diseases(9), Genetics, Aging, and Longevity in Model Organisms(7), Mitochondrial Function and Pathology(5), Genetics and Neurodevelopmental Disorders(5)

Publications31 total

Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys
International Journal of Biological Sciences·2025Open Access
Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain
Protein & Cell·2025Open Access
A Novel Genetic TDP‐43 Pig Model Mimics Multiple Key ALS‐Like Features
MedComm·2025Open Access
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
Molecular Neurodegeneration·2025· 13 citedOpen Access
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models
Journal of Clinical Investigation·2024· 21 citedOpen Access
Suppressing <i>UBE2N</i> ameliorates Alzheimer's disease pathology through the clearance of amyloid beta
Alzheimer s & Dementia·2024· 15 citedOpen Access
Large animal models for Huntington’s disease research
动物学研究·2023· 11 citedOpen Access
A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)
Advanced Science·2023· 1 citedOpen Access
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Signal Transduction and Targeted Therapy·2023· 16 citedOpen Access
A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
Advanced Science·2023· 6 citedOpen Access
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
Signal Transduction and Targeted Therapy·2023· 9 citedOpen Access
CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate
Cell Discovery·2023· 24 citedOpen Access
Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease
Nature Biomedical Engineering·2023· 57 cited
Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig
Frontiers in Cell and Developmental Biology·2023· 25 citedOpen Access
Application of CRISPR/Cas9 System in Establishing Large Animal Models
Frontiers in Cell and Developmental Biology·2022· 31 citedOpen Access
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
Protein & Cell·2021· 58 citedOpen Access
TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS
Human Molecular Genetics·2021· 19 cited
Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey
Neural Regeneration Research·2021· 10 citedOpen Access
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
Translational Psychiatry·2019· 107 citedOpen Access
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
Cell Research·2019· 91 citedOpen Access
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Frequent Co-authors

Sen Yan(23), Xiao‐Jiang Li(20), Shihua Li(15), Yingqi Lin(13), Caijuan Li(10), Weili Yang(9), Peng Yin(8), Chunhui Huang(8), Yizhi Chen(8), Xiangyu Guo(7), Shihua Li(7), Xiaoming Zheng(7), Jiawei Li(7), Xichen Song(7), Jiale Gao(7), Xiusheng Chen(6), Jianhao Wu(6), Zhaoming Liu(5), Weili Yang(5), Bofeng Han(5)