Akito Yasuhara

Taisho Pharmaceutical (Japan) — Japan

Chemistry · Physical Sciences

24h-index1.7kcitations47works0.02yr avg
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Research Topics

Catalytic C–H Functionalization Methods(17), Catalytic Cross-Coupling Reactions(12), Neuroscience and Neuropharmacology Research(11), Chemical Synthesis and Reactions(7), Receptor Mechanisms and Signaling(6)

Publications47 total

1‐メチル‐N‐(プロパン‐2‐イル)‐N‐({2‐[4‐(トリフルオロメトキシ)フェニル]ピリジン‐4‐イル}メチル)‐1H‐イミダゾール‐4‐カルボキサミドの潜在的な経口利用可能なグリシントランスポーター1阻害剤としての特定
Chemical and Pharmaceutical Bulletin·2016Open Access
Identification of 1-Methyl-<i>N</i>-(propan-2-yl)-<i>N</i>-({2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl}methyl)-1<i>H</i>-imidazole-4-carboxamide as a Potent and Orally Available Glycine Transporter 1 Inhibitor
Chemical and Pharmaceutical Bulletin·2016· 4 citedOpen Access
Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor
Journal of Pharmacological Sciences·2015· 23 citedOpen Access
Neurophysiologic and Antipsychotic Profiles of TASP0433864, a Novel Positive Allosteric Modulator of Metabotropic Glutamate 2 Receptor
Journal of Pharmacology and Experimental Therapeutics·2014· 32 cited
Metabotropic Glutamate Receptors: Potential Drug Targets for Psychiatric Disorders
The Open Medicinal Chemistry Journal·2010· 31 citedOpen Access
Metabotropic Glutamate Receptors: Potential Drug Targets for Psychiatric Disorders
The Open Medicinal Chemistry Journal·2010
Synthesis, in vitro pharmacology, and pharmacokinetic profiles of 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-1-fluorocyclopropanecarboxylic acid and its 6-heptyl ester, a potent mGluR2 antagonist
Bioorganic & Medicinal Chemistry·2008· 19 citedOpen Access
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential
Bioorganic & Medicinal Chemistry·2006· 43 cited
Synthesis, in vitro pharmacology, and structure–activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists
Bioorganic & Medicinal Chemistry·2006· 15 cited
IN VITRO AND IN VIVO EVALUATION OF THE METABOLISM AND BIOAVAILABILITY OF ESTER PRODRUGS OF MGS0039 (3-(3,4-DICHLOROBENZYLOXY)-2-AMINO-6-FLUOROBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID), A POTENT METABOTROPIC GLUTAMATE RECEPTOR ANTAGONIST
Drug Metabolism and Disposition·2005· 14 cited
Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors
Neuroscience Letters·2005· 65 cited
Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists
Journal of Medicinal Chemistry·2004· 59 citedOpen Access
Convenient Indole Synthesis from 2‐Iodoanilines and Terminal Alkynes by the Sequential Sonogashira Reaction and the Cyclization Reaction Promoted by Tetrabutylammonium Fluoride (TBAF).
ChemInform·2004
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
Neuropharmacology·2003· 250 cited
Convenient Indole Synthesis from 2-Iodoanilines and Terminal Alkynes by the Sequential Sonogashira Reaction and the Cyclization Reaction Promoted by Tetrabutylammonium Fluoride (TBAF)
Chemical and Pharmaceutical Bulletin·2003· 42 citedOpen Access
ChemInform Abstract: Convenient Indole Synthesis from Ethynylanilines with a Polymer‐Supported Fluoride.
ChemInform·2002
Convenient indole synthesis from ethynylanilines with a polymer-supported fluoride
Tetrahedron Letters·2002· 26 cited
ChemInform Abstract: Synthesis of 2,3‐Disubstituted Indole Using Palladium(II)‐Catalyzed Cyclization with Alkenylation Reaction.
ChemInform·2002
ChemInform Abstract: A Concise Synthesis of Furostifoline by Tetrabutylammonium Fluoride‐Promoted Indole Ring Formation.
ChemInform·2002
ChemInform Abstract: Cyclization Reactions of 2‐Alkynylbenzyl Alcohol and 2‐Alkynylbenzylamine Derivatives Promoted by Tetrabutylammonium Fluoride.
ChemInform·2002
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Frequent Co-authors

Takao Sakamoto(33), Naoyuki Suzuki(10), Shigeyuki Chaki(9), Atsushi Kasano(9), Yoshinori Kondo(8), Atsuro Nakazato(7), Kazunari Sakagami(6), Hiroshi Yamanaka(6), Ryoko Yoshikawa(5), Kou Hiroya(4), Mitsuyoshi Kameda(4), Masato Nakamura(4), Yousuke Takeda(4), Toshiharu Shimazaki(3), Masashi Kaneko(3), Jun-ichi Karasawa(3), Hiroshi Ohta(3), Yasunori Kawakita(3), Naoya Kawashima(2), Shigeru Okuyama(2)