Gayani Nanayakkara

University of Utah — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index1.9kcitations45works2.52yr avg
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Research Topics

Mitochondrial Function and Pathology(8), Adipose Tissue and Metabolism(7), Cardiac Ischemia and Reperfusion(6), Atherosclerosis and Cardiovascular Diseases(6), Cardiovascular Disease and Adiposity(6)

Publications45 total

Dehydration promotes intracellular lipid synthesis and accumulation
2025· 1 citedOpen Access
Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4+Foxp3+ Regulatory T Cell Immunosuppression
International Journal of Drug Discovery and Pharmacology·2024· 4 citedOpen Access
Reply to Comment on Shen H, et al. “Co-signaling receptors regulate T-cell plasticity and immune tolerance”. Frontiers in Bioscience-Landmark. 2019; 24: 96–132
Frontiers in Bioscience-Landmark·2021Open Access
Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
Redox Biology·2021· 26 citedOpen Access
A Novel Subset of CD95+ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity
Frontiers in Immunology·2021· 19 citedOpen Access
Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice
Pathogens·2020· 50 citedOpen Access
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors
Frontiers in Immunology·2019· 35 citedOpen Access
Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions
Frontiers in Oncology·2019· 26 citedOpen Access
Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs
Redox Biology·2019· 68 citedOpen Access
Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept
Archives of Biochemistry and Biophysics·2018· 92 cited
DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks
Frontiers in Physiology·2018· 22 citedOpen Access
Uremic toxins are conditional danger‐ or homeostasis‐ associated molecular patterns, which are highly selective increase rather than purely passive accumulation, in chronic kidney disease and coronary arteria disease
The FASEB Journal·2018
STAT1 (Signal Transducer and Activator of Transcription 1) Deficiency in T Cells Upregulates MHC Class II and Co‐stimulation Receptors, Suggesting that STAT1 deficiency in T Cells May Increase the Plasticity and Convert in to Atypical Antigen Presenting Cells
The FASEB Journal·2018
Increased Plasticity of FOXP3+ Treg under Pathological Conditions Convert Treg into Either Novel Treg or Th1‐Treg
The FASEB Journal·2018
GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg
Frontiers in Immunology·2018· 74 citedOpen Access
A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
Journal of Hematology & Oncology·2017· 96 citedOpen Access
Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking
Frontiers in Physiology·2017· 120 citedOpen Access
Analysis of caspase-1 regulated transcriptome in various tissues lead to identification of novel IL-1β, IL-18 and sirtuin-1 intendent pathways
The Journal of Immunology·2017
Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury
Antioxidants and Redox Signaling·2017· 75 citedOpen Access
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
Journal of Hematology & Oncology·2017· 53 citedOpen Access
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Frequent Co-authors

Xiaofeng Yang(23), Ying Shao(21), Hong Wang(19), William Y. Yang(16), Rajesh Amin(15), Eric T. Choi(15), Yu Sun(12), Hangfei Fu(11), Yafeng Li(10), Candice Johnson(10), Ramón Cueto(10), Charles Drummer(9), John C. Quindry(9), Keman Xu(9), Xiaohua Jiang(8), Xinyuan Li(7), Luqiao Wang(7), Qian Yang(7), Yifan Lu(7), Jun Yu(6)