Mathieu Le Gars

Human Vaccines Project Europe — Netherlands

Medicine · Health Sciences

21h-index5.9kcitations65works1.82yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(43), COVID-19 Clinical Research Studies(26), Influenza Virus Research Studies(9), Vaccine Coverage and Hesitancy(9), vaccines and immunoinformatics approaches(7)

Publications64 total

Immune correlates analysis of antibody responses against SARS-CoV-2 variants in the ENSEMBLE vaccine efficacy trial
iScience·2025Open Access
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
Genes and Immunity·2025· 1 citedOpen Access
Safety, immunogenicity and pregnancy outcomes in mothers and infants after vaccination with an adenovirus-vector COVID-19 vaccine during pregnancy
Human Vaccines & Immunotherapeutics·2025· 1 citedOpen Access
Vaccine-induced T cell responses correlate with reduced risk of severe COVID-19 in a placebo-controlled efficacy trial
EBioMedicine·2025· 5 citedOpen Access
The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity
2025· 1 cited
P-100. Durable immune response induced by self-amplifying mRNA (samRNA) SARS-CoV-2 vaccine candidates against variants of concern (VOC) in HIV-negative and people living with HIV (PLWH) populations in South Africa, irrespective of prior SARS-CoV-2 vaccination
Open Forum Infectious Diseases·2025Open Access
Safety and immunogenicity of Ad26.COV2.S in adolescents: Phase 2 randomized clinical trial
Human Vaccines & Immunotherapeutics·2025· 2 citedOpen Access
Safety, reactogenicity, and immunogenicity of Ad26.COV2.S co-administered with a quadrivalent standard-dose or high-dose seasonal influenza vaccine: a non-inferiority randomised controlled trial
EClinicalMedicine·2025· 1 citedOpen Access
Safety and Humoral Immunogenicity of Different Dose Levels of Ad26.COV2.S as a 2-Dose Regimen in COVID-19 Vaccine-Naïve Healthy Adults: A Phase 3 Randomized Clinical Trial
Vaccines·2024Open Access
Ad26.COV2.S COVID-19 Vaccine Safety And Immunogenicity in Adolescents 16–17 Years of Age
Journal of the Pediatric Infectious Diseases Society·2024Open Access
Modelling antibody dynamics in humans after different Ad26.COV2.S vaccination schemes
British Journal of Clinical Pharmacology·2024
Pre- and post-Ad26.COV2·S booster dose antibody levels predict COVID-19 disease risk
Vaccine·2024
Safety, reactogenicity, and immunogenicity of Ad26.COV2.S as homologous or heterologous COVID-19 booster vaccination: Results of a randomized, double-blind, phase 2 trial
Vaccine·2024· 1 citedOpen Access
Safety and immunogenicity of Ad26.COV2.S in adults: A randomised, double-blind, placebo-controlled Phase 2a dose-finding study
Vaccine·2024· 3 citedOpen Access
B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S
iScience·2024· 3 citedOpen Access
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Nature Communications·2024· 9 citedOpen Access
Mechanistic modeling projections of antibody persistence after homologous booster regimens of COVID‐19 vaccine Ad26.COV2.S in humans
CPT Pharmacometrics & Systems Pharmacology·2023· 5 citedOpen Access
Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines
iScience·2023· 21 citedOpen Access
Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features
Research Square (Research Square)·2023Open Access
Safety, reactogenicity, and immunogenicity of Ad26.COV2.S: Results of a phase 1, randomized, double-blind, placebo-controlled COVID-19 vaccine trial in Japan
Vaccine·2023· 8 citedOpen Access
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Frequent Co-authors

Jerald Sadoff(26), Hanneke Schuitemaker(24), Frank Struyf(21), Macaya Douoguih(21), Carla Truyers(15), Dan H. Barouch(13), Javier Ruiz‐Guiñazú(12), Johan Van Hoof(12), Gert C. Scheper(11), Dirk Heerwegh(11), Anne Marit de Groot(11), Jenny Hendriks(11), Vicky Cárdenas(9), Georgi Shukarev(9), Catherine A. Blish(9), Jingyou Yu(8), Abishek Chandrashekar(8), Christof Seiler(8), Susan Holmes(8), Glenda Gray(7)