Pauline C. Ting

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.4kcitations66works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(15), Neuropeptides and Animal Physiology(8), Chemical Synthesis and Analysis(8), Phosphodiesterase function and regulation(7), Antifungal resistance and susceptibility(6)

Publications66 total

Discovery of aminoquinazoline derivatives as human A2A adenosine receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2015· 13 citedOpen Access
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety
ACS Medicinal Chemistry Letters·2014· 26 citedOpen Access
Development of Novel Benzomorpholine Class of Diacylglycerol Acyltransferase I Inhibitors
ACS Medicinal Chemistry Letters·2014· 35 citedOpen Access
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2014· 12 citedOpen Access
Discovery of oral and inhaled PDE4 inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 12 cited
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety
ACS Medicinal Chemistry Letters·2013· 11 citedOpen Access
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 8 citedOpen Access
The optimization of pyridazinone series of glucan synthase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 9 citedOpen Access
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 9 citedOpen Access
Discovery of oxazole-based PDE4 inhibitors with picomolar potency
Bioorganic & Medicinal Chemistry Letters·2012· 23 citedOpen Access
Discovery of a Novel Class of Orally Active Antifungal β-1,3- <scp>d</scp> -Glucan Synthase Inhibitors
Antimicrobial Agents and Chemotherapy·2011· 75 citedOpen Access
SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 35 citedOpen Access
The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 21 citedOpen Access
Preparation of Ethyl 1‐Benzyl‐4‐Fluoropiperidine‐4‐Carboxylate
Organic Syntheses·2010
The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
European Journal of Pharmacology·2010· 25 cited
Structure and activity relationships of tartrate-based TACE inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 18 citedOpen Access
Pharmacology Of SCH900182, A Potent, Selective Inhibitor Of PDE4 For Inhaled Administration
2010· 4 cited
ChemInform Abstract: Palladium‐Catalyzed Negishi α‐Arylation of Alkylsulfones.
ChemInform·2010
Palladium-catalyzed Negishi α-arylation of alkylsulfones
Tetrahedron Letters·2009· 46 cited
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Frequent Co-authors

Robert Aslanian(23), Joe F. Lee(17), John J. Piwinski(12), Rongze Kuang(10), Scott S. Walker(8), John C. Anthes(8), Neng‐Yang Shih(8), Jianhua Cao(7), Richard W. Chapman(6), Yiming Xu(5), Paul M. McNicholas(5), Samuel B. Wainhaus(5), Todd A. Black(5), John A. Hey(5), David W. Kim(5), John H. Schwerdt(5), He‐Ping Wu(5), Paul A. Bartlett(4), Anthony Cacciapuoti(4), R. Jason Herr(4)