Christine Le Bec

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index627citations24works0.02yr avg
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Research Topics

Virus-based gene therapy research(11), Viral Infectious Diseases and Gene Expression in Insects(5), Muscle Physiology and Disorders(4), CRISPR and Genetic Engineering(4), Viral Infections and Immunology Research(4)

Publications24 total

Navigating evolving regulatory CMC guidance in the AAV gene therapy field
Cell and Gene Therapy Insights·2023
Navigating evolving regulatory CMC guidance in the AAV gene therapy field
Cell and Gene Therapy Insights·2023
Gene therapy CMC and quality control
Cell and Gene Therapy Insights·2021
Monobac System–A Single Baculovirus for the Production of rAAV
Microorganisms·2021· 17 citedOpen Access
Developing a risk mitigation plan for gene therapy manufacturing
Cell and Gene Therapy Insights·2020
Priorities for AAV vector analytics development
Cell and Gene Therapy Insights·2020· 1 cited
Advances and shortfalls in AAV vector characterization
Cell and Gene Therapy Insights·2019
Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome
Molecular Therapy — Methods & Clinical Development·2018· 59 citedOpen Access
Analytical approaches to characterize AAV vector production & purification: Advances and challenges
Cell and Gene Therapy Insights·2018· 19 cited
Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs
Molecular Therapy·2017· 108 citedOpen Access
498. Prolonged Benefit from Systemic rAAV8 in a Canine Model of Myotubular Myopathy
Molecular Therapy·2016Open Access
503. Adeno-Associated Virus Vector (AAV) Microdystrophin Gene Therapy Prolongs Survival and Restores Muscle Function in the Canine Model of Duchenne Muscular Dystrophy (DMD)
Molecular Therapy·2016· 1 citedOpen Access
Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR
Molecular Therapy — Methods & Clinical Development·2016· 86 citedOpen Access
704. Long-Term Correction of Crigler-Najjar Syndrome and Scale-Up Production of an Optimized AAV8 Vector Expressing the UGT1A1 Transgene
Molecular Therapy·2015Open Access
503. Minimally Effective Dose of Systemic AAV8-MTM1 Needed To Prolong Survival and Correct Severe Muscle Pathology in a Canine Model of X-Linked Myotubular Myopathy
Molecular Therapy·2015Open Access
MyD88 Signaling in B Cells Regulates the Production of Th1-dependent Antibodies to AAV
Molecular Therapy·2012· 54 cited
Epigenetic gene expression noise and phenotypic diversification of clonal cell populations
Differentiation·2007· 61 cited
CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding
Biochemical Journal·2006· 92 citedOpen Access
Internal Ribosome Entry Site Structural Motifs Conserved among Mammalian Fibroblast Growth Factor 1 Alternatively Spliced mRNAs
Molecular and Cellular Biology·2004· 72 citedOpen Access
Derivatives of Imidazole-4-carboxamide as Substrates for Various DNA Polymerases
Nucleosides and Nucleotides·1997· 1 cited
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Frequent Co-authors

Fulvio Mavilio(5), P. Véron(4), Federico Mingozzi(4), Samia Martin(4), David L. Mack(3), Karine Poulard(3), Melissa Goddard(3), Virginie Latournerie(3), Jessica M. Snyder(3), Robert W. Grange(3), Laurine Buscara(3), Hui Meng(3), Alan H. Beggs(3), Michael W. Lawlor(3), Martin K. Childers(3), Philippe Moullier(3), Matthias Hebben(3), Michael Brewer(3), Matthew Elverman(2), Jean‐Yves Hogrel(2)