Jayaraman Chandrasekhar

Gilead Sciences (United States) — United States

Physics and Astronomy · Physical Sciences

47h-index56.3kcitations259works0.02yr avg
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Research Topics

Advanced Chemical Physics Studies(53), Inorganic and Organometallic Chemistry(25), Photochemistry and Electron Transfer Studies(23), Organic Chemistry Cycloaddition Reactions(23), Spectroscopy and Quantum Chemical Studies(21)

Publications259 total

Enhanced utility of AI/ML methods during lead optimization by inclusion of 3D ligand information
Frontiers in Drug Discovery·2022· 11 citedOpen Access
Atropisomerism in Drug Discovery: A Medicinal Chemistry Perspective Inspired by Atropisomeric Class I PI3K Inhibitors
Accounts of Chemical Research·2022· 144 cited
Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif
ACS Medicinal Chemistry Letters·2020· 15 citedOpen Access
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases
ACS Medicinal Chemistry Letters·2020· 49 citedOpen Access
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor
Journal of Medicinal Chemistry·2018· 61 citedOpen Access
Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856
Journal of Medicinal Chemistry·2017· 29 citedOpen Access
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
Bioorganic & Medicinal Chemistry Letters·2016· 33 citedOpen Access
Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
Drug Metabolism and Disposition·2016· 42 cited
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability
Journal of Medicinal Chemistry·2016· 44 citedOpen Access
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
Journal of Medicinal Chemistry·2016· 47 citedOpen Access
CCDC 1505469: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
The JAK1/2 Inhibitor Momelotinib Does Not Inhibit Thiamine Uptake in Vitro
Blood·2015
Computational studies of transition states of reactions
2013· 1 cited
EXPLORING NEW STRUCTURAL MOTIFS USING COMPUTATIONAL METHODS
2013
Potentiality of aqueous leaf extract of Trichosanthes cucumerina Linn. on hair growth promotion in Wistar albino rats
2012· 6 cited
Behavior‐Based Screening as an Approach to Polypharmacological Ligands
2012· 5 cited
Potentiality of Hair Growth Promoting Activity of Aqueous Extract of Abrus precatorius Linn. on Wistar Albino Rats
Journal of Natural Remedies·2012· 2 cited
Molecule of the month
Resonance·2011
Use of isotopes for studying reaction mechanisms
Resonance·2011· 2 cited
Membrane stabilizing potency of two Tephrosia species.
The Journal of Phytology·2010· 14 cited
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Frequent Co-authors

William L. Jorgensen(14), Paul von Ragué Schleyer(12), Eluvathingal D. Jemmis(4), Timothy Clark(3), Scott F. Smith(3), Matthew P. Repasky(3), Stéphane Perreault(3), Leena Patel(3), V. Ramamurthy(3), Raghavan B. Sunoj(3), Günther W. Spitznagel(2), Juan G. Andrade(2), A. Rathna(2), Brian T. Luke(2), N. Sathyamurthy(2), Hirdyesh Mishra(2), H.B. Tripathi(2), Manoranjan Panda(2), Krishnan Raghavachari(2), E.‐U. WUERTHWEIN(2)