Larry S. Barak

Duke University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

55h-index13.8kcitations102works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(71), Neuropeptides and Animal Physiology(35), Protein Kinase Regulation and GTPase Signaling(16), Neuroscience and Neuropharmacology Research(14), Neurotransmitter Receptor Influence on Behavior(9)

Publications102 total

A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
Nature Communications·2019· 42 citedOpen Access
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs
ACS Pharmacology & Translational Science·2019· 12 citedOpen Access
Design, synthesis and biological evaluation of GPR55 agonists
Bioorganic & Medicinal Chemistry·2017· 15 citedOpen Access
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness
Journal of Biological Chemistry·2017· 25 citedOpen Access
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin
The FASEB Journal·2017· 30 citedOpen Access
Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis
Bioorganic & Medicinal Chemistry·2017· 21 citedOpen Access
Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands
ACS Chemical Biology·2017· 9 citedOpen Access
ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse
ACS Chemical Biology·2016· 44 citedOpen Access
Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones
Bioorganic & Medicinal Chemistry Letters·2016· 6 citedOpen Access
Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa- 1 ,3-diazole-phallacidin (phallacidin/phalloidin/immunofluorescence/cytoplasmic streaming/Chara australis)
2016
A rapid and affordable screening platform for membrane protein trafficking
BMC Biology·2015· 23 citedOpen Access
Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure
Bioorganic & Medicinal Chemistry·2015· 67 citedOpen Access
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions
Development·2015· 25 cited
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth
Breast Cancer Research·2015· 45 citedOpen Access
Additional file 9: File S4. of A rapid and affordable screening platform for membrane protein trafficking
Figshare·2015Open Access
Additional file 8: File S3. of A rapid and affordable screening platform for membrane protein trafficking
Figshare·2015Open Access
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions
Journal of Cell Science·2015· 51 citedOpen Access
Additional file 6: File S1. of A rapid and affordable screening platform for membrane protein trafficking
Figshare·2015Open Access
Additional file 10: File S5. of A rapid and affordable screening platform for membrane protein trafficking
Figshare·2015Open Access
Additional file 7: File S2. of A rapid and affordable screening platform for membrane protein trafficking
Figshare·2015Open Access
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Frequent Co-authors

Marc G. Caron(39), Stephen S. G. Ferguson(12), Stéphane A. Laporte(11), Robert H. Oakley(7), Jie Zhang(7), Robert J. Lefkowitz(7), Luc Ménard(6), Yushi Bai(6), Jason A. Holt(5), Wei Chen(5), Raul R. Gainetdinov(5), Anne-Marie Colapietro(4), Haleli Sharir(4), Mary E. Abood(4), Tatyana D. Sotnikova(4), Marc G. Caron(4), Richard T. Premont(3), Xiu-Rong Ren(3), Ali Salahpour(3), Bernard Masri(3)