Kosuke Yusa

Kyoto University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index10.8kcitations146works3.12yr avg
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Research Topics

CRISPR and Genetic Engineering(88), Pluripotent Stem Cells Research(27), Advanced biosensing and bioanalysis techniques(13), RNA Interference and Gene Delivery(13), Protein Degradation and Inhibitors(12)

Publications146 total

CDK12/13 inhibitor, CTX-439, suppresses tumor growth and potentiates BCL-2 family blockade
2026Open Access
Genome-wide CRISPR screen identifies ACSL3 as a regulator of lipotoxicity and progression of MASLD
Hepatology Communications·2026Open Access
Clonal evolution and therapeutic vulnerabilities in SETBP1-mutated leukemia: Insights from physiological mouse model and integrative functional screens
Blood·2025
Inhibition of lysine acetyltransferases p300/CBP overcomes BTK inhibitor resistance in a xenograft model of Mantle Cell Lymphoma by suppressing MYC signaling
Blood·2025
Abstract C009: Development of an innovative anticancer drug TBP1901, an injectable prodrug of curcumin, for the treatment of multiple myeloma
Molecular Cancer Therapeutics·2025
Development of a Synthetic Lethality‐Based Combination Therapy Using <scp>LIG1</scp> and <scp>PARP</scp> Inhibitors for Prostate Cancer
Cancer Science·2025· 1 citedOpen Access
Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour
2025Open Access
HVJ-E links Apolipoprotein d to antitumor effects
Journal for ImmunoTherapy of Cancer·2025Open Access
Abstract 1636: Novel CDK12/13 inhibitor CTX-439 downregulates MCL1 via transcriptional mRNA read-through and synergistically acts with BCL-XL inhibitors for cancer therapy
Cancer Research·2025· 1 cited
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Nature·2025· 25 citedOpen Access
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
Nature Cancer·2025· 5 cited
Inhibition of p300/CBP Overcomes BTK Inhibitor Resistance in MCL By Counteracting IL-6/JAK/STAT3 Signaling
Blood·2024
Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection
iScience·2024· 8 citedOpen Access
Abstract 3301: Translational research of CDK12/13 inhibitor, CTX-439, informing clinical trial strategy
Cancer Research·2024· 1 cited
Genome‐wide loss‐of‐function genetic screen identifies <scp>INSIG2</scp> as the vulnerability of hepatitis B virus‐integrated hepatoma cells
Cancer Science·2024· 5 citedOpen Access
RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations
Communications Biology·2023· 15 citedOpen Access
Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia
Blood·2023· 3 citedOpen Access
CNOT4 Knockout Induces Proteasome Inhibitor Resistance in Multiple Myeloma Cells
Blood·2023Open Access
Inhibition of Lysine Acetyltransferases p300/CBP Overcomes BTK Inhibitor Resistance in Mantle Cell Lymphoma Cells
Blood·2023Open Access
Sphingomyelin synthase 1 supports two steps of rubella virus life cycle
iScience·2023· 2 citedOpen Access
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Frequent Co-authors

Allan Bradley(14), Junji Takeda(10), Francesco Iorio(8), Kyoji Horie(8), Fiona M. Behan(7), Mathew J. Garnett(7), Emanuel Gonçalves(6), George S. Vassiliou(6), Hiroko Koike-Yusa(5), Yilong Li(5), Roland Rad(5), Charlotte Beaver(4), Euan A. Stronach(4), Julio Sáez-Rodríguez(4), Meng Amy Li(4), Konstantinos Tzelepis(4), Hannes Ponstingl(4), Nathalie Conte(4), Fengtang Yang(4), Vincent W. Keng(4)