George S. Vassiliou

Wellcome/MRC Cambridge Stem Cell Institute — United Kingdom

Medicine · Health Sciences

59h-index20.8kcitations343works3.32yr avg
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Research Topics

Acute Myeloid Leukemia Research(166), Cancer Genomics and Diagnostics(69), Myeloproliferative Neoplasms: Diagnosis and Treatment(60), Protein Degradation and Inhibitors(41), RNA modifications and cancer(29)

Publications343 total

BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia
Annals of Hematology·2026Open Access
Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.
JCI Insight·2025Open Access
Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.
Apollo (University of Cambridge)·2025Open Access
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer
Signal Transduction and Targeted Therapy·2025· 1 citedOpen Access
A continuum of inherited telomere dysfunction links TERT rare variants to age-related diseases
Blood·2025Open Access
DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells
2025Open Access
BCOR Mutations Define a Therapeutic Vulnerability to DHODH Inhibition in Acute Myeloid Leukemia
2025Open Access
Polymer-based culture system enables expansion of human haematopoietic stem and progenitor cells while preserving ageing-associated transcriptional programs
2025Open Access
Epigenetic clues from cancer’s past foretell its future
Nature·2025
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis
Nature Genetics·2025· 7 citedOpen Access
Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study
Open Heart·2025Open Access
CHIC: A machine learning framework for inferring the presence of high‐risk clonal hematopoiesis using complete blood count data from 431,531 UK Biobank participants
HemaSphere·2025· 1 citedOpen Access
Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in <i>NPM1</i>-mutant AML
Blood·2025· 1 citedOpen Access
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein
Nature Biotechnology·2025· 16 citedOpen Access
Abstract 1768: Pharmacological inhibition of METTL1 as a novel therapeutic strategy against aggressive malignancies
Cancer Research·2025
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Nature·2025· 25 citedOpen Access
The molecular basis of haematological malignancies
2025· 1 cited
Clonal haematopoiesis
2025
Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis
Nature Genetics·2025· 8 citedOpen Access
Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.
2025
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Frequent Co-authors

Allan Bradley(12), Roland Rad(11), Oliver M. Dovey(10), Peter J. Campbell(9), Konstantinos Tzelepis(9), Carolyn Grove(9), Anthony R. Green(8), Brian J.P. Huntly(8), Ignacio Varela(8), E. Joanna Baxter(7), Étienne De Braekeleer(7), Hannes Ponstingl(6), Annalisa Mupo(6), Margarete A. Fabre(6), Pentao Liu(6), Anthony J. Bench(5), Malgorzata Gozdecka(5), Elli Papaemmanuil(5), Jonathan Cooper(5), Kosuke Yusa(5)