Lyn H. Jones

Harvard University — United States

Chemistry · Physical Sciences

46h-index9.1kcitations176works4.52yr avg
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Research Topics

Click Chemistry and Applications(47), Protein Degradation and Inhibitors(43), Chemical Synthesis and Analysis(30), Monoclonal and Polyclonal Antibodies Research(21), Peptidase Inhibition and Analysis(21)

Publications176 total

Ligandability assessment of interferonopathy‐associated proteins using chemoproteomics
British Journal of Pharmacology·2025
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation
Molecular Cell·2025· 6 citedOpen Access
Property-Based Optimization of Cereblon-Based Molecular Glue Degraders
ACS Medicinal Chemistry Letters·2025Open Access
Advances in sulfonyl exchange chemical biology: expanding druggable target space
Chemical Science·2025· 9 citedOpen Access
Introduction to the themed collection on ‘Induced-Proximity Pharmacology’
RSC Medicinal Chemistry·2025Open Access
Structure-guided design of a truncated heterobivalent chemical probe degrader of IRE1α
RSC Medicinal Chemistry·2025· 2 citedOpen Access
Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype
Blood·2024Open Access
Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency
UNC Libraries·2024Open Access
Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency
ACS Chemical Biology·2024· 7 citedOpen Access
27 (PB015): Targeted degradation of NTAQ1 using a CRBN molecular glue to study the N-degron pathway
European Journal of Cancer·2024
Photoaffinity labelling with small molecules
Nature Reviews Methods Primers·2024· 32 cited
The ability of immunomodulatory imide drugs (IMiDs) to inhibit the polarization of T helper cells towards Th2 phenotype depends on cereblon
The Journal of Immunology·2024
Synthetic modification of protein surfaces to mediate induced-proximity pharmacology
RSC Medicinal Chemistry·2024· 5 citedOpen Access
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators
RSC Medicinal Chemistry·2024· 2 citedOpen Access
The Minimum Protein Staple? – Towards ‘bio’-Baldwin's rules <i>via</i> inter-phosphosite linking in the MEK1 activation loop
Chemical Science·2023· 4 citedOpen Access
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange
ACS Medicinal Chemistry Letters·2023· 20 citedOpen Access
The promise of targeted protein degradation approaches
Trends in Pharmacological Sciences·2023· 2 citedOpen Access
ReSPONDINg TACtically, degrading strategically
Trends in Pharmacological Sciences·2023· 2 cited
Clinical Translation of Targeted Protein Degraders
Clinical Pharmacology & Therapeutics·2023· 39 citedOpen Access
Covalent drug discovery using sulfur(VI) fluoride exchange warheads
Expert Opinion on Drug Discovery·2023· 28 cited
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Frequent Co-authors

Erik C. Hett(5), Ralph P. Robinson(4), Mark E. Bunnage(4), Fabien Vincent(4), Olugbeminiyi Fadeyi(3), Nathanael S. Gray(3), Arjun Narayanan(3), Kieran F. Geoghegan(3), Ariamala Gopalsamy(3), Robert E. Kyne(3), Shenping Liu(3), Lee R. Roberts(3), Jianwei Che(3), David M. Beal(3), Alan Armstrong(3), Matthew D. Selby(3), Alexandria P. Taylor(2), David C. Blakemore(2), Tinghu Zhang(2), Eugene L. Piatnitski Chekler(2)