Ariamala Gopalsamy

AstraZeneca (Brazil) — Brazil

Medicine · Health Sciences

27h-index2.3kcitations81works5.82yr avg
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Research Topics

Hepatitis C virus research(11), Chemical Synthesis and Analysis(10), HIV/AIDS drug development and treatment(8), Quinazolinone synthesis and applications(8), Synthesis and biological activity(7)

Publications81 total

Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome
Journal of Medicinal Chemistry·2025· 2 cited
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders
ACS Medicinal Chemistry Letters·2025· 1 cited
Synthetic lethality: targeting the SMARCA2 bromodomain for degradation in SMARCA4-deficient tumors – a review of patent literature from 2019–June 2023
Expert Opinion on Therapeutic Patents·2024· 13 cited
Synthetic lethality: targeting SMARCA2 ATPase in SMARCA4-deficient tumors – a review of patent literature from 2019–30 June 2023
Expert Opinion on Therapeutic Patents·2024· 7 cited
Photocatalyzed Decarboxylative Addition of N-Substituted Acetic Acids to Aldehydes
The Journal of Organic Chemistry·2023· 8 cited
Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment
European Journal of Organic Chemistry·2022· 3 cited
Selectivity through Targeted Protein Degradation (TPD)
Journal of Medicinal Chemistry·2022· 38 citedOpen Access
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease
Journal of Medicinal Chemistry·2020· 40 citedOpen Access
Photoredox Catalysis: 1,4-Conjugate Addition of <i>N</i>-Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of <i>N</i>-Substituted Acetic Acids
Organic Letters·2020· 14 cited
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1
Bioorganic & Medicinal Chemistry·2020· 21 citedOpen Access
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Journal of Medicinal Chemistry·2018· 166 citedOpen Access
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels
PLoS ONE·2017· 18 citedOpen Access
Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue
ACS Chemical Biology·2017· 134 cited
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)
Journal of Medicinal Chemistry·2017· 20 citedOpen Access
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Scientific Reports·2016· 60 citedOpen Access
Selectivity Determination of a Small Molecule Chemical Probe Using Protein Microarray and Affinity Capture Techniques
ACS Combinatorial Science·2016· 12 cited
Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells
Organic & Biomolecular Chemistry·2016· 24 cited
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS
Molecular BioSystems·2015· 13 cited
Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes
ACS Chemical Biology·2015· 191 cited
CHAPTER 3. Anti-Inflammatory Drugs
RSC drug discovery/RSC drug discovery series·2013· 2 cited
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Frequent Co-authors

Mengxiao Shi(12), John W. Ellingboe(12), Lyn H. Jones(9), Girija Krishnamurthy(7), Boris Feld(7), Robert E. Kyne(6), Anita Y. M. Howe(6), Mark Orlowski(6), Erik C. Hett(5), Hua Xu(5), Michael A. Tones(5), Yongbo Hu(5), Carol A. Menard(4), Arjun Narayanan(4), Mihir D. Parikh(4), Ralph P. Robinson(4), Jean‐Baptiste Telliez(4), Kitae Lim(4), Gregory Ciszewski(4), Kaapjoo Park(4)