Yongbo Hu

Second Military Medical University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index3.2kcitations80works4.92yr avg
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Research Topics

Melanoma and MAPK Pathways(11), Alzheimer's disease research and treatments(8), Biochemical and Molecular Research(7), Protein Kinase Regulation and GTPase Signaling(6), PI3K/AKT/mTOR signaling in cancer(6)

Publications80 total

Superwater as a generative AI framework to predict water molecule positions on protein structures
Communications Chemistry·2025Open Access
Nanoplastics exposure exacerbates Aβ plaque deposition in Alzheimer’s disease mice by inducing microglia pyroptosis
Ecotoxicology and Environmental Safety·2025· 10 citedOpen Access
Exploring the mediating role of plasma lipidome in the pathway from gut microbiota to dementia: A Mendelian randomization study
Archives of Medical Science·2025Open Access
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
PLoS Pathogens·2024· 2 citedOpen Access
Combined Mendelian randomization and quantitative proteomics analysis to study the influence of thyroid dysfunction on acute ischemic stroke
MedComm – Future Medicine·2024Open Access
Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification
Translational Neurodegeneration·2024· 11 citedOpen Access
A potent and selective reaction hijacking inhibitor of <i>Plasmodium falciparum</i> tyrosine tRNA synthetase exhibits single dose oral efficacy <i>in vivo</i>
2024Open Access
A diagnostic model for Parkinson’s disease based on circadian rhythm-related genes
Journal of Translational Medicine·2024· 7 citedOpen Access
Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer’s disease
Brain·2024· 14 citedOpen Access
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non–small cell lung cancer
Bioorganic & Medicinal Chemistry Letters·2022· 21 citedOpen Access
SIAH2 regulates colorectal cancer tumorigenesis via PI3K/ATK signaling pathway
Tissue and Cell·2022· 12 cited
Adult-Onset Neuronal Ceroid Lipofuscinosis With a Novel DNAJC5 Mutation Exhibits Aberrant Protein Palmitoylation
Frontiers in Aging Neuroscience·2022· 14 citedOpen Access
The China Alzheimer Report 2022
General Psychiatry·2022· 325 citedOpen Access
microRNA‐425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies
Aging Cell·2021· 12 citedOpen Access
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route
Journal of Medicinal Chemistry·2021· 41 citedOpen Access
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer
Gene·2021· 35 cited
CCDC 2013738: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Mobocertinib (TAK-788): A Targeted Inhibitor of <i>EGFR</i> Exon 20 Insertion Mutants in Non–Small Cell Lung Cancer
Cancer Discovery·2021· 188 citedOpen Access
Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
Journal of Medicinal Chemistry·2021· 194 citedOpen Access
Multifunctional Nanostructure RAP‐RL Rescues Alzheimer's Cognitive Deficits through Remodeling the Neurovascular Unit
Advanced Science·2020· 15 citedOpen Access
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Frequent Co-authors

Ru‐Jing Ren(7), Gang Wang(7), Teruna J. Siahaan(7), Bryan M. Lewis(6), Eileen Frommer(6), Karen Collins(6), Donald Wojciechowicz(6), Ariamala Gopalsamy(5), Jeremy I. Levin(5), Larry Feldberg(4), Steven Kim(4), Robert Mallon(4), Russell G. Dushin(4), Alexandra E. Gould(3), Yiming He(3), Yu‐Xiong Su(3), Hailun Cui(3), Fusao Takusagawa(3), Xiaoda Yang(3), Dan Yin(3)