Fusao Takusagawa

University of Kansas — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index5.2kcitations224works0.02yr avg
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Research Topics

Biochemical and Molecular Research(25), Folate and B Vitamins Research(21), Metal complexes synthesis and properties(20), Enzyme Structure and Function(20), DNA and Nucleic Acid Chemistry(19)

Publications224 total

Microsomal Prostaglandin E Synthase Type 2 (mPGES2) Is a Glutathione-dependent Heme Protein, and Dithiothreitol Dissociates the Bound Heme to Produce Active Prostaglandin E2 Synthase in Vitro
Journal of Biological Chemistry·2013· 28 citedOpen Access
Discovery of Novel Types of Inhibitors of<i>S</i>-Adenosylmethionine Synthesis by Virtual Screening
Journal of Medicinal Chemistry·2009· 8 citedOpen Access
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations
Archives of Biochemistry and Biophysics·2009· 6 citedOpen Access
Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2008· 9 cited
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: Crystal structure and site-directed mutagenesis studies
Biochimica et Biophysica Acta (BBA) - General Subjects·2008· 14 cited
PGH<sub>2</sub> Degradation Pathway Catalyzed by GSH−Heme Complex Bound Microsomal Prostaglandin E<sub>2</sub> Synthase Type 2:  The First Example of a Dual-Function Enzyme<sup>,</sup>
Biochemistry·2007· 34 cited
[Structure, function, and stability of cytolethal distending toxin].
PubMed·2007
GSH-heme bound microsomal prostaglandin E synthase
2007
Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents
Biochemical Pharmacology·2006· 32 cited
S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine
2006
Enzymatic and biochemical properties of a novel human serine dehydratase isoform
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics·2006· 11 cited
Prostaglandin F<sub>2</sub><sub>α</sub> Formation from Prostaglandin H<sub>2</sub> by Prostaglandin F Synthase (PGFS):  Crystal Structure of PGFS Containing Bimatoprost<sup>,</sup>
Biochemistry·2006· 53 cited
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): Crystal structure of CDT from <i>Actinobacillus actinomycetemcomitans</i>
Protein Science·2006· 43 citedOpen Access
Crystal structure of prostaglandin F synathase containing bimatoprost
2005
Catalytic mechanism of S-adenosylhomocysteine hydrolase: Roles of His 54, Asp130, Glu155, Lys185, and Aspl89
The International Journal of Biochemistry & Cell Biology·2005· 34 cited
Crystal Structure and Possible Catalytic Mechanism of Microsomal Prostaglandin E Synthase Type 2 (mPGES-2)
Journal of Molecular Biology·2005· 78 cited
K185N mutated S-adenosylhomocysteine hydrolase
2004
Catalytic Mechanism of Guanidinoacetate Methyltransferase:  Crystal Structures of Guanidinoacetate Methyltransferase Ternary Complexes<sup>,</sup>
Biochemistry·2004· 34 cited
Some biochemical and histochemical properties of human liver serine dehydratase
The International Journal of Biochemistry & Cell Biology·2004· 12 cited
Guanidinoacetate methyltransferase containing S-adenosylhomocysteine and guanidinoacetate
2004
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Frequent Co-authors

Junichi Komoto(12), Hirofumi Ogawa(9), Yoshimi Takata(9), Tomoharu Gomi(8), Motoji Fujioka(8), Taro Yamada(8), Thomas F. Koetzle(6), Yafei Huang(6), S. Kamitori(5), George D. Markham(4), Helen M. Berman(4), Kiyoshi Konishi(4), Joseph A. Heppert(4), Jeffrey Aubé(4), David Vander Velde(4), Yongbo Hu(3), Kikuko Watanabe(3), Prem C. Srivastava(3), Akira Shimada(3), Zhuji Fu(2)